MedKoo Cat#: 319693 | Name: Delparantag

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Delparantag, also known as PMX-60056, is a heparins antidote designed to restore coagulation to help manage the balance of antithrombosis and anticoagulation and reduce the incidence of bleeding in certain interventional cardiology procedures, such as Percutaneous Coronary Intervention (PCI) and Coronary Arterial Bypass Graft (CABG), as well as, treat bleeding associated with low molecular weight heparins. Delparantag reverses the most common anticoagulants used in the hospital setting, heparin, and its derivative, low molecular weight heparin (LMWH).

Chemical Structure

Delparantag
Delparantag
CAS#872454-31-4 (free base)

Theoretical Analysis

MedKoo Cat#: 319693

Name: Delparantag

CAS#: 872454-31-4 (free base)

Chemical Formula: C56H79N13O12

Exact Mass: 1125.5971

Molecular Weight: 1126.33

Elemental Analysis: C, 59.72; H, 7.07; N, 16.17; O, 17.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1294448-66-0 (5HCl) 872454-31-4 (free base)
Synonym
PMX-60056; PMX60056; PMX 60056; Delparantag
IUPAC/Chemical Name
N-((S)-6-amino-1-((3-(((S)-6-amino-1-((3-(((S)-6-amino-1-((3-carbamoyl-4-methoxyphenyl)amino)-1-oxohexan-2-yl)carbamoyl)-4-methoxyphenyl)amino)-1-oxohexan-2-yl)carbamoyl)-4-methoxyphenyl)amino)-1-oxohexan-2-yl)-5-((S)-2,6-diaminohexanamido)-2-methoxybenzamide
InChi Key
PWFIFNGOPQUNIT-ITMZJIMRSA-N
InChi Code
InChI=1S/C56H79N13O12/c1-78-45-21-17-33(29-37(45)49(62)70)64-54(75)42(14-6-10-26-58)67-51(72)39-31-35(19-23-47(39)80-3)66-56(77)44(16-8-12-28-60)69-52(73)40-32-36(20-24-48(40)81-4)65-55(76)43(15-7-11-27-59)68-50(71)38-30-34(18-22-46(38)79-2)63-53(74)41(61)13-5-9-25-57/h17-24,29-32,41-44H,5-16,25-28,57-61H2,1-4H3,(H2,62,70)(H,63,74)(H,64,75)(H,65,76)(H,66,77)(H,67,72)(H,68,71)(H,69,73)/t41-,42-,43-,44-/m0/s1
SMILES Code
COC1=C(C=C(C=C1)NC(=O)[C@H](CCCCN)N)C(=O)N[C@@H](CCCCN)C(=O)NC2=CC(=C(C=C2)OC)C(=O)N[C@@H](CCCCN)C(=O)NC3=CC(=C(C=C3)OC)C(=O)N[C@@H](CCCCN)C(=O)NC4=CC(=C(C=C4)OC)C(=O)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,126.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mahan CE. A 1-year drug utilization evaluation of protamine in hospitalized patients to identify possible future roles of heparin and low molecular weight heparin reversal agents. J Thromb Thrombolysis. 2014 Apr;37(3):271-8. doi: 10.1007/s11239-013-0927-7. PubMed PMID: 23653171. 2: Kuziej J, Litinas E, Hoppensteadt DA, Liu D, Walenga JM, Fareed J, Jeske W. In vivo neutralization of unfractionated heparin and low-molecular-weight heparin by a novel salicylamide derivative. Clin Appl Thromb Hemost. 2010 Aug;16(4):377-86. doi: 10.1177/1076029610366439. Epub 2010 May 11. PubMed PMID: 20460347.