Decoglurant, also known as Ro 4995819, is a negative allosteric modulator of the mGlu2 and mGlu3 receptors which was under development by Roche for the adjunctive treatment of major depressive disorder. Decoglurant progressed as far as phase II clinical trials but was ultimately discontinued from further development due to disappointing efficacy results.
MedKoo Cat#: 319669
Name: Decoglurant
CAS#: 911115-16-7
Chemical Formula: C21H11F6N5
Exact Mass: 447.0919
Molecular Weight: 447.34
Elemental Analysis: C, 56.38; H, 2.48; F, 25.48; N, 15.66
The following data is based on the product molecular weight 447.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
