Esmolol Hydrochloride is the hydrochloride salt form of esmolol, a short and rapid-acting beta adrenergic antagonist belonging to the class II anti-arrhythmic drugs and devoid of intrinsic sympathomimetic activity. Esmolol hydrochloride competitively blocks beta-1 adrenergic receptors in cardiac muscle and reduces the contractility and cardiac rate of heart muscle, thereby decreasing cardiac output and myocardial oxygen demands. This agent also decreases sympathetic output centrally and blocks renin secretion. At higher doses, esmolol hydrochloride also blocks beta-2 receptors located in bronchial and vascular smooth muscle, thereby leading to smooth muscle relaxation.
MedKoo Cat#: 317785
Name: Esmolol Hydrochloride
CAS#: 81161-17-3 (HCl)
Chemical Formula: C16H26ClNO4
Exact Mass: 0.0000
Molecular Weight: 331.84
Elemental Analysis: C, 57.91; H, 7.90; Cl, 10.68; N, 4.22; O, 19.29
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 63.7 | 191.87 | |
| DMF | 25.0 | 75.34 | |
| Ethanol | 45.5 | 137.11 | |
| PBS (pH 7.2) | 10.0 | 30.14 | |
| Water | 58.0 | 174.78 |
The following data is based on the product molecular weight 331.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
