GSK1842799 is a selective S1P1 receptor agonist for multiple sclerosis. Upon phosphorylation, GSK1842799 showed subnanomole S1P1 agonist activity with >1000× selectivity over S1P3. GSK1842799 demonstrated good oral bioavailability. On the basis of the favorable in vitro ADME and in vivo PK/PD properties as well as broad toxicology evaluations, GSK1842799 was selected as a candidate for further clinical.
MedKoo Cat#: 206582
Name: GSK1842799 HCl
CAS#: 1277165-15-7 (HCl)
Chemical Formula: C20H30Cl2F3N3O2S
Exact Mass: 431.1854
Molecular Weight: 504.43
Elemental Analysis: C, 47.62; H, 5.99; Cl, 14.06; F, 11.30; N, 8.33; O, 6.34; S, 6.36
The following data is based on the product molecular weight 504.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
