Futibatinib, also known as TAS-120 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor TAS-120 selectively and irreversibly binds to and inhibits FGFR, which may result in the inhibition of both the FGFR-mediated signal transduction pathway and tumor cell proliferation, and increased cell death in FGFR-overexpressing tumor cells. FGFR is a receptor tyrosine kinase essential to tumor cell proliferation, differentiation and survival and its expression is upregulated in many tumor cell types.
MedKoo Cat#: 206535
Name: Futibatinib (TAS-120)
CAS#: 1448169-71-8
Chemical Formula: C22H22N6O3
Exact Mass: 418.1753
Molecular Weight: 418.46
Elemental Analysis: C, 63.15; H, 5.30; N, 20.08; O, 11.47
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.0 | 90.81 | |
| DMF | 30.0 | 71.69 | |
| DMF:PBS (pH 7.2) (1:5) | 0.2 | 0.38 | |
| Ethanol | 0.5 | 1.19 |
The following data is based on the product molecular weight 418.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
