XCF-37B is a HIF-1 inhibitor. XCF-37b demonstrated safety on NCM460 normal cells, exhibited the same antiangiogenic activity as the reference sunitinib, and significantly inhibited the formation of neovascularization in the absence of vascular networks. Furthermore, XCF-37b effectively suppressed VEGF-induced HUVEC growth with an IC50 value of 8.56 μM. XCF-37b clearly stopped tumors from migrating by suppressing the activity of VEGF/HIF-1α signaling pathway.
MedKoo Cat#: 128241
Name: XCF-37B
CAS#: N/A
Chemical Formula: C26H22N2O4
Exact Mass: 426.1580
Molecular Weight: 426.47
Elemental Analysis: C, 73.23; H, 5.20; N, 6.57; O, 15.01
The following data is based on the product molecular weight 426.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
