2B182C | CAS#unknown | TLR4-NF-κB reporter/primary cell activator

MedKoo Cat#: 464150 | Name: 2B182C

Description:

WARNING: This product is for research use only, not for human or veterinary use.

2B182C is a novel potent activator of both human and mouse TLR4-NF-κB reporter cells and primary cells, inducing serum anti-HA and anti-NA IgG1 levels.

Chemical Structure

2B182C

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464150

Name: 2B182C

CAS#: unknown

Chemical Formula: C29H28N4O3S

Exact Mass: 512.1882

Molecular Weight: 512.63

Elemental Analysis: C, 67.95; H, 5.51; N, 10.93; O, 9.36; S, 6.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

2B182C; 2B 182C; 2B-182C;

IUPAC/Chemical Name

N-cyclohexyl-2-((8-(furan-2-yl)-5-methyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetamide

InChi Key

YDUMLYSAUSSREZ-UHFFFAOYSA-N

InChi Code

InChI=1S/C29H28N4O3S/c1-32-23-15-14-19(24-13-8-16-36-24)17-22(23)26-27(32)28(35)33(21-11-6-3-7-12-21)29(31-26)37-18-25(34)30-20-9-4-2-5-10-20/h3,6-8,11-17,20H,2,4-5,9-10,18H2,1H3,(H,30,34)

SMILES Code

O=C(NC1CCCCC1)CSC2=NC3=C(C(N2C4=CC=CC=C4)=O)N(C)C5=C3C=C(C6=CC=CO6)C=C5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 512.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sato-Kaneko F, Yao S, Lao FS, Shpigelman J, Messer K, Pu M, Shukla NM, Cottam HB, Chan M, Chu PJ, Burkhart D, Schoener R, Matsutani T, Carson DA, Corr M, Hayashi T. A Novel Synthetic Dual Agonistic Liposomal TLR4/7 Adjuvant Promotes Broad Immune Responses in an Influenza Vaccine With Minimal Reactogenicity. Front Immunol. 2020 Jun 19;11:1207. doi: 10.3389/fimmu.2020.01207. PMID: 32636840; PMCID: PMC7318308.