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MedKoo Cat#: 317454 | Name: Ceftriaxone Sodium
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ceftriaxone sodium is an antibiotic, a third-generation cephalosporin. Like other third-generation cephalosporins, it has broad-spectrum activity against Gram-positive bacteria and expanded Gram-negative coverage compared to second-generation agents. This includes pneumonia, ear infections, skin infections, urinary tract infections, gonorrhea, pelvic inflammatory disease, septisis, bone and joint infections, intra-abdominal infections, and meningitis. It is also used preoperatively to reduce the risk of postoperative infections. It is administered by intravenous or intramuscular injection.

Chemical Structure

Ceftriaxone Sodium
CAS#74578-69-1 (sodium)

Theoretical Analysis

MedKoo Cat#: 317454

Name: Ceftriaxone Sodium

CAS#: 74578-69-1 (sodium)

Chemical Formula: C18H17N8NaO7S3

Exact Mass: 0.0000

Molecular Weight: 576.56

Elemental Analysis: C, 37.50; H, 2.97; N, 19.43; Na, 3.99; O, 19.42; S, 16.68

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 Weeks
2g USD 350.00 2 Weeks
5g USD 650.00 2 Weeks
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Related CAS #
73384-59-5 (free base) 74578-69-1 (sodium)
Synonym
Ceftriaxone Sodium; Ceftriaxone sodium hydrate; Ceftriaxonesodium; (E)-Ceftriaxone Sodium; Rocephine; Roche Brand of Ceftriaxone Sodium; Sodium, Ceftriaxone; Syntex Brand of Ceftriaxone Sodium; Tacex; Terbac;
IUPAC/Chemical Name
sodium (6R,7R)-7-((E)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(((2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChi Key
YOBPSXOHCHDCMU-IXIFSOOLSA-M
InChi Code
InChI=1S/C18H18N8O7S3.Na/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7;/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32);/q;+1/p-1/b24-8+;/t9-,15-;/m1./s1
SMILES Code
O=C(C(N12)=C(CSC(N(C)NC3=O)=NC3=O)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N/OC)=O)C1=O)[O-].[Na+]
Appearance
White to light yellow solid powder.
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 576.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Xue J, Jia YH, Li J, Yin LH, Hu CQ. [Subtype classification of ceftriaxone sodium and its influence on the quality of product]. Yao Xue Xue Bao. 2014 Jul;49(7):1034-8. Chinese. PubMed PMID: 25233636. 2: Pan J, Ye Z, Cai X, Wang L, Cao Z. Biophysical study on the interaction of ceftriaxone sodium with bovine serum albumin using spectroscopic methods. J Biochem Mol Toxicol. 2012 Dec;26(12):487-92. doi: 10.1002/jbt.21446. Epub 2012 Nov 21. PubMed PMID: 23169700. 3: Tange M, Hattori Y, Otsuka M, Yoshida M, Haginaka J, Uchida T. Comparison of the dissolution rate of ceftriaxone sodium preparations for injection. Chem Pharm Bull (Tokyo). 2013;61(11):1121-9. Epub 2013 Aug 16. PubMed PMID: 23955165. 4: Sun H, Wang H, Ge X. Simultaneous determination of the combined drugs of ceftriaxone sodium, metronidazole, and levofloxacin in human urine by high-performance liquid chromatography. J Clin Lab Anal. 2012 Nov;26(6):486-92. doi: 10.1002/jcla.21551. PubMed PMID: 23143633. 5: Yao Y, Zhou R, Wang Y. Fatal adverse effects of injected ceftriaxone sodium in China. Pharmacoepidemiol Drug Saf. 2012 Nov;21(11):1197-201. doi: 10.1002/pds.3232. Epub 2012 Jul 4. Review. PubMed PMID: 22761158. 6: Aléssio PV, Salgado HR. Development and validation of a successful microbiological agar assay for determination of ceftriaxone sodium in powder for injectable solution. Pharmaceutics. 2012 Jun 29;4(3):334-42. doi: 10.3390/pharmaceutics4030334. PubMed PMID: 24300294; PubMed Central PMCID: PMC3834915. 7: Zaki NM, Hafez MM. Enhanced antibacterial effect of ceftriaxone sodium-loaded chitosan nanoparticles against intracellular Salmonella typhimurium. AAPS PharmSciTech. 2012 Jun;13(2):411-21. doi: 10.1208/s12249-012-9758-7. Epub 2012 Feb 23. PubMed PMID: 22359159; PubMed Central PMCID: PMC3364366. 8: Tange M, Yoshida M, Nakai Y, Uchida T. Comparison between original and generic versions of ceftriaxone sodium preparation for injection: compatibility with calcium-containing product. Chem Pharm Bull (Tokyo). 2012;60(4):429-34. PubMed PMID: 22466725. 9: Akl MA, Ahmed MA, Ramadan A. Validation of an HPLC-UV method for the determination of ceftriaxone sodium residues on stainless steel surface of pharmaceutical manufacturing equipments. J Pharm Biomed Anal. 2011 May 15;55(2):247-52. doi: 10.1016/j.jpba.2011.01.020. Epub 2011 Jan 25. PubMed PMID: 21330092. 10: Zhang XH, Cao DM, Zhao SY, Gong P, Hei DQ, Zhang HQ. Gamma radiolysis of ceftriaxone sodium for water treatment: assessments of the activity. Water Sci Technol. 2011;63(12):2767-74. PubMed PMID: 22049697. 11: Sato Y, Morita H, Wakasugi H, Iijima S, Kawashima E, Wakayama Y, Yoshimura A. Reversible choreoathetosis after the administration of ceftriaxone sodium in patients with end-stage renal disease. Am J Med Sci. 2010 Nov;340(5):382-4. doi: 10.1097/MAJ.0b013e3181ec063b. PubMed PMID: 20724905. 12: Towfigh S, Pasternak J, Poirier A, Leister H, Babinchak T. A multicentre, open-label, randomized comparative study of tigecycline versus ceftriaxone sodium plus metronidazole for the treatment of hospitalized subjects with complicated intra-abdominal infections. Clin Microbiol Infect. 2010 Aug;16(8):1274-81. doi: 10.1111/j.1469-0691.2010.03122.x. PubMed PMID: 20670293. 13: Nakai Y, Tokuyama E, Yoshida M, Uchida T. Prediction of incompatibility of ceftriaxone sodium with calcium ions using the ionic product. Yakugaku Zasshi. 2010 Jan;130(1):95-102. PubMed PMID: 20046072. 14: Nakai Y, Tokuyama E, Yoshida M, Uchida T. Incompatibility of ceftriaxone sodium with calcium-containing products. Yakugaku Zasshi. 2009 Nov;129(11):1385-92. PubMed PMID: 19881211. 15: Attama AA, Okafor CE, Builders PF, Okorie O. Formulation and in vitro evaluation of a PEGylated microscopic lipospheres delivery system for ceftriaxone sodium. Drug Deliv. 2009 Nov;16(8):448-57. doi: 10.3109/10717540903334959. PubMed PMID: 19839789. 16: Zhao X, Jin SH, Hu CQ. The effect of rubber closures on the haze state of ceftriaxone sodium for injection. Drug Dev Ind Pharm. 2007 Jan;33(1):35-44. PubMed PMID: 17192249. 17: Stevenson AM. Ceftriaxone sodium. MCN Am J Matern Child Nurs. 1998 Sep-Oct;23(5):272. PubMed PMID: 9747091. 18: Bailey LC, Orosz ST Jr. Stability of ceftriaxone sodium and metronidazole hydrochloride. Am J Health Syst Pharm. 1997 Feb 15;54(4):424-7. PubMed PMID: 9043566. 19: Plumridge RJ, Rieck AM, Annus TP, Langton SR. Stability of ceftriaxone sodium in polypropylene syringes at -20, 4, and 20 degrees C. Am J Health Syst Pharm. 1996 Oct 1;53(19):2320-3. PubMed PMID: 8893073. 20: Rivers TE, Webster AA. Stability of ceftizoxime sodium, ceftriaxone sodium, and ceftazidime with metronidazole in ready-to-use metronidazole bags. Am J Health Syst Pharm. 1995 Nov 15;52(22):2568-70. PubMed PMID: 8590243.

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