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MedKoo Cat#: 317609 | Name: Dienestrol
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dienestrol is a synthetic, non-steroidal estrogen structurally related to stilbestrol. It is used, usually as the cream, in the treatment of menopausal and postmenopausal symptoms. It is an estrogen receptor agonist. Estrogens work partly by increasing a normal clear discharge from the vagina and making the vulva and urethra healthy. Using or applying an estrogen relieves or lessens: dryness and soreness in the vagina, itching, redness, or soreness of the vulva. Conditions that are treated with vaginal estrogens include a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), and inflammation of the urethra (atrophic urethritis).

Chemical Structure

Dienestrol
CAS#84-17-3

Theoretical Analysis

MedKoo Cat#: 317609

Name: Dienestrol

CAS#: 84-17-3

Chemical Formula: C18H18O2

Exact Mass: 266.1307

Molecular Weight: 266.33

Elemental Analysis: C, 81.17; H, 6.81; O, 12.01

Price and Availability

Size Price Availability Quantity
100mg USD 250.00 2 weeks
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Related CAS #
No Data
Synonym
Dienestrol; Dehydrostilbestrol; Dienoestrol; Sexadien; Restrol; E,E-Dienestrol; Cycladiene; NSC 59809; NSC59809; NSC-59809
IUPAC/Chemical Name
4-[(2E,4E)-4-(4-hydroxyphenyl)hexa-2,4-dien-3-yl]phenol
InChi Key
NFDFQCUYFHCNBW-SCGPFSFSSA-N
InChi Code
InChI=1S/C18H18O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h3-12,19-20H,1-2H3/b17-3+,18-4+
SMILES Code
C/C=C(/C(=C/C)/C1=CC=C(C=C1)O)\C2=CC=C(C=C2)O
Appearance
White to off-white crystalline powder.
Purity
>96% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 266.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hu WY, Kang XJ, Zhang C, Yang J, Ling R, Liu EH, Li P. Packed-fiber solid-phase extraction coupled with high performance liquid chromatography-tandem mass spectrometry for determination of diethylstilbestrol, hexestrol, and dienestrol residues in milk products. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Apr 15;957:7-13. doi: 10.1016/j.jchromb.2014.02.036. Epub 2014 Mar 2. PubMed PMID: 24636894. 2: Nong S, Lin F, Huang X, Yuan D. Preparation of a stir bar sorptive extraction coating based on molecularly imprinted polymer and its application in the extraction of dienestrol and hexestrol in complicated samples. Se Pu. 2012 Nov;30(11):1133-42. PubMed PMID: 23451515. 3: Xu Q, Wang M, Yu S, Tao Q, Tang M. Trace analysis of diethylstilbestrol, dienestrol and hexestrol in environmental water by Nylon 6 nanofibers mat-based solid-phase extraction coupled with liquid chromatography-mass spectrometry. Analyst. 2011 Dec 7;136(23):5030-7. doi: 10.1039/c1an15494j. Epub 2011 Oct 12. PubMed PMID: 21994916. 4: Roner MR, Carraher CE Jr, Shahi K, Ashida Y, Barot G. Ability of Group IVB metallocene polyethers containing dienestrol to arrest the growth of selected cancer cell lines. BMC Cancer. 2009 Oct 7;9:358. doi: 10.1186/1471-2407-9-358. PubMed PMID: 19811643; PubMed Central PMCID: PMC2765989. 5: Dickson LC, MacNeil JD, Reid J, Fesser AC. Validation of screening method for residues of diethylstilbestrol, dienestrol, hexestrol, and zeranol in bovine urine using immunoaffinity chromatography and gas chromatography/mass spectrometry. J AOAC Int. 2003 Jul-Aug;86(4):631-9. PubMed PMID: 14509418. 6: Inano H, Suzuki K, Ishii-Ohba H, Yamanouchi H, Takahashi M, Wakabayashi K. Promotive effects of diethylstilbestrol, its metabolite (Z,Z-dienestrol) and a stereoisomer of the metabolite (E,E-dienestrol) in tumorigenesis of rat mammary glands pregnancy-dependently initiated with radiation. Carcinogenesis. 1993 Oct;14(10):2157-63. PubMed PMID: 8222069. 7: Bagnati R, Castelli MG, Airoldi L, Paleologo Oriundi M, Ubaldi A, Fanelli R. Analysis of diethylstilbestrol, dienestrol and hexestrol in biological samples by immunoaffinity extraction and gas chromatography-negative-ion chemical ionization mass spectrometry. J Chromatogr. 1990 May 18;527(2):267-78. PubMed PMID: 2167323. 8: Metzler M, McLachlan JA. Oxidative metabolism of the synthetic estrogens hexestrol and dienestrol indicates reactive intermediates. Adv Exp Med Biol. 1981;136 Pt A:829-37. PubMed PMID: 6283819. 9: Bailey LC, Bailey CA. Analysis of dienestrol and its dosage forms by high-performance liquid chromatography. J Pharm Sci. 1979 Apr;68(4):508-10. PubMed PMID: 438981. 10: Weidenfeld J, Carter P, Reinhold VN, Tanner SB 4th, Engel LL. Metabolism of diethylstilbestrol: identification of a catechol derived from dienestrol. Biomed Mass Spectrom. 1978 Oct;5(10):587-90. PubMed PMID: 106901.