Synonym
RO5263397; RO-5263397; RO 5263397.
IUPAC/Chemical Name
(S)-4-(3-fluoro-2-methylphenyl)-4,5-dihydrooxazol-2-amine dihydrochloride
InChi Key
GZJSFLYZAYEEKB-KLQYNRQASA-N
InChi Code
InChI=1S/C10H11FN2O.2ClH/c1-6-7(3-2-4-8(6)11)9-5-14-10(12)13-9;;/h2-4,9H,5H2,1H3,(H2,12,13);2*1H/t9-;;/m1../s1
SMILES Code
NC1=N[C@@H](C2=C(C)C(F)=CC=C2)CO1.[H]Cl.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
267.13
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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Jun 3. PubMed PMID: 26048337.
2: Jing L, Zhang Y, Li JX. Effects of the trace amine associated receptor 1
agonist RO5263397 on abuse-related behavioral indices of methamphetamine in rats.
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2015 Feb;352(2):358-67. doi: 10.1124/jpet.114.220194. Epub 2014 Dec 12. PubMed
PMID: 25503386.
4: Thorn DA, Jing L, Qiu Y, Gancarz-Kausch AM, Galuska CM, Dietz DM, Zhang Y, Li
JX. Effects of the trace amine-associated receptor 1 agonist RO5263397 on
abuse-related effects of cocaine in rats. Neuropsychopharmacology. 2014
Sep;39(10):2309-16. doi: 10.1038/npp.2014.91. Epub 2014 Apr 18. PubMed PMID:
24743376; PubMed Central PMCID: PMC4138753.
5: Thorn DA, Zhang C, Zhang Y, Li JX. The trace amine associated receptor 1
agonist RO5263397 attenuates the induction of cocaine behavioral sensitization in
rats. Neurosci Lett. 2014 Apr 30;566:67-71. doi: 10.1016/j.neulet.2014.02.024.
Epub 2014 Feb 21. PubMed PMID: 24561093; PubMed Central PMCID: PMC3991844.
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S, Groebke Zbinden K, Galley G, Norcross RD, Tuerck D, Bruns A, Morairty SR,
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for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like
activity, improve cognition and control body weight. Mol Psychiatry. 2013
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