TRK-380 | TAC-301 | CAS# | β3-adrenoceptor agonist.

MedKoo Cat#: 522559 | Name: TRK-380

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TRK-380, also known as TAC-301, is a potent and selective β3-adrenoceptor agonist. TRK-380 ameliorates formalin-induced pollakiuria in rats and carbachol-induced bladder contraction in dogs. TRK-380 induces 37.6% reduction in bladder contraction induced by carbachol.

Chemical Structure

TRK-380

CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 522559

Name: TRK-380

CAS#: Unknown

Chemical Formula:

Exact Mass:

Molecular Weight:

Elemental Analysis:

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

TRK-380; TRK 380; TRK380; TAC-301; TAC 301; TAC301.

IUPAC/Chemical Name

Unknown

InChi Key

InChi Code

SMILES Code

Unknown

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 0.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Thiagamoorthy G, Giarenis I, Cardozo L. Early investigational β3 adreno-receptor agonists for the management of the overactive bladder syndrome. Expert Opin Investig Drugs. 2015;24(10):1299-306. doi: 10.1517/13543784.2015.1076390. Epub 2015 Aug 14. PubMed PMID: 26292923. 2: Kanie S, Otsuka A, Yoshikawa S, Kobayashi R, Itaba S, Yokokawa H, Tajima Y, Ozono S, Hayashi R, Mochizuki H. TRK-380, a novel selective human β3-adrenoceptor agonist, ameliorates formalin-induced pollakiuria in rats and carbachol-induced bladder contraction in dogs. Urology. 2013 Oct;82(4):975.e7-975.e12. doi: 10.1016/j.urology.2013.07.016. PubMed PMID: 24075004. 3: Matsumoto R, Otsuka A, Suzuki T, Shinbo H, Mizuno T, Kurita Y, Mugiya S, Ozono S. Expression and functional role of β3 -adrenoceptors in the human ureter. Int J Urol. 2013 Oct;20(10):1007-14. doi: 10.1111/iju.12093. Epub 2013 Jan 29. PubMed PMID: 23360304. 4: Kanie S, Otsuka A, Yoshikawa S, Morimoto T, Hareyama N, Okazaki S, Kobayashi R, Hasebe K, Nakao K, Hayashi R, Mochizuki H, Matsumoto R, Ozono S. Pharmacological effect of TRK-380, a novel selective human β3-adrenoceptor agonist, on mammalian detrusor strips. Urology. 2012 Mar;79(3):744.e1-7. doi: 10.1016/j.urology.2011.08.080. Epub 2011 Dec 23. PubMed PMID: 22197203.