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MedKoo Cat#: 317572 | Name: Cyclopentolate HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cyclopentolate is a parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia. It is commonly used during pediatric eye examinations to dilate the eye (mydriatic), prevent accommodation of the eye to different distances (cycloplegic), and block specific receptors called muscarinic receptors (muscarinic antagonist). Cyclopentolate is also administered as an atropine substitute to reverse muscarinic and central nervous system effects of indirect cholinomimetic (anti-AChase) administration.

Chemical Structure

Cyclopentolate HCl
Cyclopentolate HCl
CAS#5870-29-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 317572

Name: Cyclopentolate HCl

CAS#: 5870-29-1 (HCl)

Chemical Formula: C17H26ClNO3

Exact Mass: 291.1834

Molecular Weight: 327.85

Elemental Analysis: C, 62.28; H, 7.99; Cl, 10.81; N, 4.27; O, 14.64

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
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Related CAS #
5870-29-1 (HCl) 512-15-2 (free base).
Synonym
Cyclopentolate; Ciclopentolato; Cyclopentolatum; Cyclogyl; Cyclopentylate; Mydrilate; Pentolair; (±)-Cyclopentolate HCl
IUPAC/Chemical Name
2-(dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate hydrochloride
InChi Key
VEXZGXHMUGYJMC-UHFFFAOYSA-N
InChi Code
InChI=1S/ClH/h1H
SMILES Code
O=C(OCCN(C)C)C(C1(O)CCCC1)C2=CC=CC=C2.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 327.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Costa D, Leiva M, Coyo N, Laguna F, Ríos J, Peña Gimenez MT. Effect of topical 1% cyclopentolate hydrochloride on tear production, pupil size, and intraocular pressure in healthy Beagles. Vet Ophthalmol. 2015 Oct 17. doi: 10.1111/vop.12323. [Epub ahead of print] PubMed PMID: 26475235. 2: Mohamed GG, Rizk MS, Zaky Frag EY. Spectrophotometric Determination of Distigmine Bromide, Cyclopentolate HCl, Diaveridine HCl and Tetrahydrozoline HCl via Charge Transfer Complex Formation with TCNQ and TCNE Reagents. Iran J Pharm Res. 2015 Summer;14(3):701-14. PubMed PMID: 26330858; PubMed Central PMCID: PMC4518098. 3: Neffendorf JE, Mota PM, Xue K, Hildebrand GD. Efficacy and safety of phenylephrine 2.5% with cyclopentolate 0.5% for retinopathy of prematurity screening in 1246 eye examinations. Eur J Ophthalmol. 2015 May-Jun;25(3):249-53. doi: 10.5301/ejo.5000540. Epub 2014 Nov 14. PubMed PMID: 25449644. 4: Arici C, Turk A, Ceylan OM, Kola M, Hurmeric V. Effects of 1% cyclopentolate hydrochloride on anterior segment parameters obtained with Pentacam in young adults. Arq Bras Oftalmol. 2014 Aug;77(4):228-32. PubMed PMID: 25410174. 5: Güler E, Güragaç FB, Tenlik A, Yagci R, Arslanyilmaz Z, Balci M. Influences of topical cyclopentolate on anterior chamber parameters with a dual-Scheimpflug analyzer in healthy children. J Pediatr Ophthalmol Strabismus. 2015 Jan-Feb;52(1):26-30. doi: 10.3928/01913913-20141111-02. Epub 2014 Nov 19. PubMed PMID: 25403030. 6: Arici C, Turk A, Ceylan OM, Kola M. The effect of topical 1% cyclopentolate on IOLMaster biometry. Optom Vis Sci. 2014 Nov;91(11):1343-7. doi: 10.1097/OPX.0000000000000388. PubMed PMID: 25237761. 7: Ka AM, De Medeiros ME, Sow AS, Ndiaye PA, Weladji C, Diallo HM, Wane AM, Diagne JP, Kane A, Ndiaye JM, Ndoye Roth PA, Ba EA, Ndiaye MR. [Objective refraction in black children: cyclopentolate and tropicamide combination, a reliable alternative to atropine?]. J Fr Ophtalmol. 2014 Nov;37(9):689-94. doi: 10.1016/j.jfo.2014.05.005. Epub 2014 Sep 6. French. PubMed PMID: 25199485. 8: Oltulu R, Satirtav G, Kerimoğlu H, Zengin N, Ozkağnici A, Okka M. Influence of cyclopentolate hydrochloride on corneal biomechanical properties in healthy individuals. Eye Contact Lens. 2014 Sep;40(5):309-11. doi: 10.1097/ICL.0000000000000058. PubMed PMID: 25083778. 9: Diesner SC, Bannert C, Gruber S, Dehlink E, Eiwegger T, Szepfalusi Z. The mydriaticum cyclopentolate induces severe allergy in a 5-year-old child. Klin Padiatr. 2014 Jul;226(4):252-3. doi: 10.1055/s-0034-1375700. Epub 2014 Jul 10. PubMed PMID: 25010132. 10: Rozette NA, Matragoon S, Sethi S, Goei S, Manasco KB, El-Remessy AB. Systemic effects of ophthalmic cyclopentolate on body weight in neonatal mice. Neonatology. 2014;106(1):37-41. doi: 10.1159/000358228. Epub 2014 Apr 25. PubMed PMID: 24776747.

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