PX20606 | PX-102 | CAS#1268244-85-4 | 1268245-19-7 | 1268244-86-5 | FXR agonist

MedKoo Cat#: 522554 | Name: PX20606

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PX20606, also known as PX-102, is a FXR agonist. PX20606 induces high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-) mice. PX20606 demonstrated potent plasma cholesterol-lowering activity that affected all lipoprotein species.

Chemical Structure

PX20606

CAS#1268244-85-4 (trans racemic)

Theoretical Analysis

MedKoo Cat#: 522554

Name: PX20606

CAS#: 1268244-85-4 (trans racemic)

Chemical Formula: C29H22Cl3NO4

Exact Mass: 553.0614

Molecular Weight: 554.85

Elemental Analysis: C, 62.78; H, 4.00; Cl, 19.17; N, 2.52; O, 11.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1268245-19-7 (racemic),1268244-85-4 (trans racemic) 1268244-88-7 (trans isomer) 1268244-87-6 (-) 1268244-86-5 (tris)

Synonym

PX20606; PX-20606; PX 20606; PX-102; PX 102; PX102. Px-104; Px104; Px 104;

IUPAC/Chemical Name

4-((1R,2R)-2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)benzoic acid

InChi Key

XBUXXJUEBFDQHD-NHCUHLMSSA-N

InChi Code

InChI=1S/C29H22Cl3NO4/c30-23-2-1-3-24(31)26(23)27-22(28(37-33-27)16-6-7-16)14-36-18-10-11-19(25(32)12-18)21-13-20(21)15-4-8-17(9-5-15)29(34)35/h1-5,8-12,16,20-21H,6-7,13-14H2,(H,34,35)/t20-,21-/m1/s1

SMILES Code

O=C(O)C1=CC=C([C@@H]2[C@@H](C3=CC=C(OCC4=C(C5CC5)ON=C4C6=C(Cl)C=CC=C6Cl)C=C3Cl)C2)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Related CAS# 1268245-19-7 ( PX20606 free acid); 1268245-21-1 ( PX20606 tris salt). 1268244-85-4 ( PX20606 trans isomer); 1268244-86-5 ( PX20606 trans isomer, tris salt).

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 554.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Deuschle U, Birkel M, Hambruch E, Hornberger M, Kinzel O, Perović-Ottstadt S, Schulz A, Hahn U, Burnet M, Kremoser C. The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine-rich glycoprotein. Int J Cancer. 2015 Jun 1;136(11):2693-704. doi: 10.1002/ijc.29312. Epub 2014 Nov 13. PubMed PMID: 25363753. 2: Hambruch E, Miyazaki-Anzai S, Hahn U, Matysik S, Boettcher A, Perović-Ottstadt S, Schlüter T, Kinzel O, Krol HD, Deuschle U, Burnet M, Levi M, Schmitz G, Miyazaki M, Kremoser C. Synthetic farnesoid X receptor agonists induce high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-) mice. J Pharmacol Exp Ther. 2012 Dec;343(3):556-67. doi: 10.1124/jpet.112.196519. Epub 2012 Aug 23. PubMed PMID: 22918042.