Cromoglicate sodium hydrate | CAS#15826-37-6 (sodium) | Mast Cell Stabilizer

MedKoo Cat#: 317566 | Name: Cromoglicate sodium hydrate

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cromoglicic acid , cromolyn (USAN), cromoglycate (former BAN), or cromoglicate, is traditionally described as a mast cell stabilizer, and is commonly marketed as the sodium salt sodium cromoglicate or cromolyn sodium. This drug prevents the release of inflammatory chemicals such as histamine from mast cells. Because of their convenience (and perceived safety), leukotriene receptor antagonists have largely replaced it as the non-corticosteroid treatment of choice in the treatment of asthma. Cromoglicic acid requires administration four times daily, and does not provide additive benefit in combination with inhaled corticosteroids.

Chemical Structure

Cromoglicate sodium hydrate

CAS#Cromoglicate sodium hydrate

Theoretical Analysis

MedKoo Cat#: 317566

Name: Cromoglicate sodium hydrate

CAS#: Cromoglicate sodium hydrate

Chemical Formula: C23H20Na2O14

Exact Mass: 468.0693

Molecular Weight: 566.38

Elemental Analysis: C, 48.78; H, 3.56; Na, 8.12; O, 39.55

Price and Availability

Size	Price	Availability
1g	USD 250.00	2 Weeks
2g	USD 350.00	2 Weeks
5g	USD 650.00	2 Weeks
10g	USD 950.00	2 Weeks

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Related CAS #

16110-51-3 (free acid) 107032-81-5 (sulfate) 15826-37-6 (sodium) Cromoglicate sodium hydrate

Synonym

Cromolyn; Cromoglicic acid; Cromolyn Disodium Hydrate; Cromoglicate sodium hydrate; Disodium Cromoglycate Hydrate

IUPAC/Chemical Name

5,5'-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylic acid] disodium trihydrate

InChi Key

IJNSAEWXFZZBTC-UHFFFAOYSA-L

InChi Code

InChI=1S/C23H16O11.2Na.3H2O/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30;;;;;/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30);;;3*1H2/q;2*+1;;;/p-2

SMILES Code

OC(COC1=C2C(C=C(C([O-])=O)OC2=CC=C1)=O)COC3=C4C(C=C(C([O-])=O)OC4=CC=C3)=O.[H]O[H].[H]O[H].[H]O[H].[Na+].[Na+]

Appearance

White to off-white solid powder.

Purity

98% (HPLC), contained ~ 10% water.

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO, not in water	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 566.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Tavano L, Nicoletta FP, Picci N, Muzzalupo R. Cromolyn as surface active drug (surfadrug): Effect of the self-association on diffusion and percutaneous permeation. Colloids Surf B Biointerfaces. 2015 Dec 8;139:132-137. doi: 10.1016/j.colsurfb.2015.12.010. [Epub ahead of print] PubMed PMID: 26705827. 2: Patel RR, Chaurasia S, Khan G, Chaubey P, Kumar N, Mishra B. Cromolyn sodium encapsulated PLGA nanoparticles: An attempt to improve intestinal permeation. Int J Biol Macromol. 2015 Dec 3;83:249-258. doi: 10.1016/j.ijbiomac.2015.11.084. [Epub ahead of print] PubMed PMID: 26656593. 3: Johnson C, Huynh V, Hargrove L, Kennedy L, Graf-Eaton A, Owens J, Trzeciakowski JP, Hodges K, DeMorrow S, Han Y, Wong L, Alpini G, Francis H. Inhibition of Mast Cell-Derived Histamine Decreases Human Cholangiocarcinoma Growth and Differentiation via c-Kit/Stem Cell Factor-Dependent Signaling. Am J Pathol. 2015 Nov 18. pii: S0002-9440(15)00578-7. doi: 10.1016/j.ajpath.2015.09.016. [Epub ahead of print] PubMed PMID: 26597881. 4: Levy D, Edut S, Baraz-Goldstein R, Rubovitch V, Defrin R, Bree D, Gariepy H, Zhao J, Pick CG. Responses of dural mast cells in concussive and blast models of mild traumatic brain injury in mice: Potential implications for post-traumatic headache. Cephalalgia. 2015 Nov 12. pii: 0333102415617412. [Epub ahead of print] PubMed PMID: 26566937. 5: Kelly JV. Generalized, well-dispersed rash · wheal development after tactile irritation · normal vital signs · Dx? J Fam Pract. 2015 Oct;64(10):645-7. PubMed PMID: 26551471. 6: Mereu A, Tedó G, Moeser AJ, Rimbach G, Ipharraguerre IR. Cromolyn-mediated improvement of intestinal barrier function is associated with enhanced piglet performance after weaning. BMC Vet Res. 2015 Oct 28;11:274. doi: 10.1186/s12917-015-0588-1. PubMed PMID: 26510713; PubMed Central PMCID: PMC4624645. 7: Choi JS, Kim JK, Yang YJ, Kim Y, Kim P, Park SG, Cho EY, Lee DH, Choi JW. Identification of cromolyn sodium as an anti-fibrotic agent targeting both hepatocytes and hepatic stellate cells. Pharmacol Res. 2015 Dec;102:176-83. doi: 10.1016/j.phrs.2015.10.002. Epub 2015 Oct 22. PubMed PMID: 26453959. 8: Pongcharoen P, Fleischer AB Jr. An evidence-based review of systemic treatments for itch. Eur J Pain. 2016 Jan;20(1):24-31. doi: 10.1002/ejp.766. Epub 2015 Sep 28. Review. PubMed PMID: 26416344. 9: Zhu LB, Lin KQ, Zhang XM, Lin J. [Sodium cromoglycate attenuates experimental endometriosis in rats by regulating mast cells]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2015 May;44(3):278-84. Chinese. PubMed PMID: 26350008. 10: Yokooji T, Matsuo H. Sodium Cromoglycate Prevents Exacerbation of IgE-Mediated Food-Allergic Reaction Induced by Aspirin in a Rat Model of Egg Allergy. Int Arch Allergy Immunol. 2015;167(3):193-202. doi: 10.1159/000437328. Epub 2015 Aug 25. PubMed PMID: 26329011.