ST247 | CAS#1356497-91-0 | PPAR β/δ agonist

MedKoo Cat#: 522550 | Name: ST247

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ST247 is a PPAR β/δ selective inverse agonist. ST247 IC50 = 19 nm vs. GSK0660 IC50 = 210 nM.

Chemical Structure

ST247

CAS#1356497-91-0

Theoretical Analysis

MedKoo Cat#: 522550

Name: ST247

CAS#: 1356497-91-0

Chemical Formula: C19H26N2O5S2

Exact Mass: 426.1283

Molecular Weight: 426.55

Elemental Analysis: C, 53.50; H, 6.14; N, 6.57; O, 18.75; S, 15.03

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 500.00	2 Weeks

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Synonym

ST247; ST-247; ST 247.

IUPAC/Chemical Name

methyl 3-(N-(4-(hexylamino)-2-methoxyphenyl)sulfamoyl)thiophene-2-carboxylate

InChi Key

MRWCGEOYGFZZCJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H26N2O5S2/c1-4-5-6-7-11-20-14-8-9-15(16(13-14)25-2)21-28(23,24)17-10-12-27-18(17)19(22)26-3/h8-10,12-13,20-21H,4-7,11H2,1-3H3

SMILES Code

O=C(C1=C(S(=O)(NC2=CC=C(NCCCCCC)C=C2OC)=O)C=CS1)OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Certificate of Analysis

View CoA: current batch, Lot#M23P01S28

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

ST247 IC50 = 19 nm vs. GSK0660 IC50 = 210 nM.

In vitro activity:

ST247 exhibited higher affinity to PPARβ/δ than GSK0660, enhanced corepressor interaction, and down-regulated target gene ANGPTL4. ST247 acted as an inverse agonist and modulated PPARβ/δ-independent functions. Reference: Mol Pharmacol. 2011 Nov;80(5):828-38. https://pubmed.ncbi.nlm.nih.gov/21862691/

In vivo activity:

To be determined

Preparing Stock Solutions

The following data is based on the product molecular weight 426.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Naruhn S, Toth PM, Adhikary T, Kaddatz K, Pape V, Dörr S, Klebe G, Müller-Brüsselbach S, Diederich WE, Müller R. High-affinity peroxisome proliferator-activated receptor β/δ-specific ligands with pure antagonistic or inverse agonistic properties. Mol Pharmacol. 2011 Nov;80(5):828-38. doi: 10.1124/mol.111.074039. Epub 2011 Aug 23. PMID: 21862691.

In vitro protocol:

In vivo protocol:

To be determined

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Changes in the clonal nature and antibiotic resistance profiles of methicillin-resistant Staphylococcus aureus isolates associated with spread of the EMRSA-15 clone in a tertiary care Portuguese hospital. J Clin Microbiol. 2007 Sep;45(9):2881-8. doi: 10.1128/JCM.00603-07. Epub 2007 Jul 11. PMID: 17626175; PMCID: PMC2045296. 16: Krziwanek K, Luger C, Sammer B, Stumvoll S, Stammler M, Sagel U, Witte W, Mittermayer H. MRSA in Austria--an overview. Clin Microbiol Infect. 2008 Mar;14(3):250-9. doi: 10.1111/j.1469-0691.2007.01896.x. Epub 2007 Dec 5. PMID: 18070133. 17: Łuczak-Kadłubowska A, Sulikowska A, Empel J, Piasecka A, Orczykowska M, Kozinska A, Hryniewicz W. Countrywide molecular survey of methicillin-resistant Staphylococcus aureus strains in Poland. J Clin Microbiol. 2008 Sep;46(9):2930-7. doi: 10.1128/JCM.00869-08. Epub 2008 Jul 9. PMID: 18614662; PMCID: PMC2546761. 18: Nulens E, Stobberingh EE, Smeets E, van Dessel H, Welling MA, Sebastian S, van Tiel FH, Beisser PS, Deurenberg RH. Genetic diversity of methicillin- resistant Staphylococcus aureus in a tertiary hospital in The Netherlands between 2002 and 2006. Eur J Clin Microbiol Infect Dis. 2009 Jun;28(6):631-9. doi: 10.1007/s10096-008-0686-0. Epub 2009 Jan 8. PMID: 19130105. 19: Campanile F, Bongiorno D, Borbone S, Stefani S. Hospital-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) in Italy. Ann Clin Microbiol Antimicrob. 2009 Jun 24;8:22. doi: 10.1186/1476-0711-8-22. PMID: 19552801; PMCID: PMC2708121. 20: Budimir A, Deurenberg RH, Bosnjak Z, Stobberingh EE, Cetkovic H, Kalenic S. A variant of the Southern German clone of methicillin-resistant Staphylococcus aureus is predominant in Croatia. Clin Microbiol Infect. 2010 Aug;16(8):1077-83. doi: 10.1111/j.1469-0691.2009.03042.x. Epub 2009 Sep 2. PMID: 19732087.