Verdiperstat | AZD-3241 | CAS#890655-80-8 | Myeloperoxidase Inhibitor

MedKoo Cat#: 319590 | Name: Verdiperstat

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Verdiperstat, also known as AZD-3241, is a selective and irreversible inhibitor of myeloperoxidase currently being developed to delay progression in patients with neurodegenerative brain disorders.

Chemical Structure

Verdiperstat

CAS#890655-80-8

Theoretical Analysis

MedKoo Cat#: 319590

Name: Verdiperstat

CAS#: 890655-80-8

Chemical Formula: C11H15N3O2S

Exact Mass: 253.0885

Molecular Weight: 253.32

Elemental Analysis: C, 52.16; H, 5.97; N, 16.59; O, 12.63; S, 12.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

AZD-3241; AZD 3241; AZD3241; Verdiperstat; CAS#890655-80-8.

IUPAC/Chemical Name

1-[2-(propan-2-yloxy)ethyl]-2-sulfanylidene-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

InChi Key

FVJCUZCRPIMVLB-UHFFFAOYSA-N

InChi Code

InChI=1S/C11H15N3O2S/c1-7(2)16-6-5-14-8-3-4-12-9(8)10(15)13-11(14)17/h3-4,7,12H,5-6H2,1-2H3,(H,13,15,17)

SMILES Code

O=C(N1)C(NC=C2)=C2N(CCOC(C)C)C1=S

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 253.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kaindlstorfer C, Sommer P, Georgievska B, Mather RJ, Kugler AR, Poewe W, Wenning GK, Stefanova N. Failure of Neuroprotection Despite Microglial Suppression by Delayed-Start Myeloperoxidase Inhibition in a Model of Advanced Multiple System Atrophy: Clinical Implications. Neurotox Res. 2015 Oct;28(3):185-94. doi: 10.1007/s12640-015-9547-7. Epub 2015 Jul 21. PubMed PMID: 26194617; PubMed Central PMCID: PMC4556742. 2: Jucaite A, Svenningsson P, Rinne JO, Cselényi Z, Varnäs K, Johnström P, Amini N, Kirjavainen A, Helin S, Minkwitz M, Kugler AR, Posener JA, Budd S, Halldin C, Varrone A, Farde L. Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease. Brain. 2015 Sep;138(Pt 9):2687-700. doi: 10.1093/brain/awv184. Epub 2015 Jul 1. PubMed PMID: 26137956. 3: Johnström P, Bergman L, Varnäs K, Malmquist J, Halldin C, Farde L. Development of rapid multistep carbon-11 radiosynthesis of the myeloperoxidase inhibitor AZD3241 to assess brain exposure by PET microdosing. Nucl Med Biol. 2015 Jun;42(6):555-60. doi: 10.1016/j.nucmedbio.2015.02.001. Epub 2015 Feb 8. PubMed PMID: 25726760.