Theliatinib, also known as xiliertinib and HMPL-309, is a novel small molecule, epidermal growth factor receptor tyrosine kinase inhibitor with potential antineoplastic and anti-angiogenesis activities. In vitro studies suggest that Theliatinib is a potent EGFR kinase inhibitor with good kinase selectivity and in vivo data demonstrated broad spectrum anti-tumor activity via oral dosing in multiple xerographs such as A-431, Bcap-37 and Fadu.
MedKoo Cat#: 206503
Name: Theliatinib free base
CAS#: 1353644-70-8 (free base)
Chemical Formula: C25H26N6O2
Exact Mass: 442.2117
Molecular Weight: 442.52
Elemental Analysis: C, 67.86; H, 5.92; N, 18.99; O, 7.23
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.0 | 106.21 |
The following data is based on the product molecular weight 442.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
