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MedKoo Cat#: 317504 | Name: Chlordiazepoxide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chlordiazepoxide is a sedative/hypnotic drug and benzodiazepine. Chlordiazepoxide was the first benzodiazepine to be synthesized and the discovery of chlordiazepoxide was by pure chance. Chlordiazepoxide and other benzodiazepines were initially accepted with widespread public approval but were followed with widespread public disapproval and recommendations for more restrictive medical guidelines for its use. Chlordiazepoxide has a medium to long half-life but its active metabolite has a very long half-life. The drug has amnestic, anticonvulsant, anxiolytic, hypnotic and skeletal muscle relaxant properties. Chlordiazepoxide is discontinued.

Chemical Structure

Chlordiazepoxide
Chlordiazepoxide
CAS#58-25-3

Theoretical Analysis

MedKoo Cat#: 317504

Name: Chlordiazepoxide

CAS#: 58-25-3

Chemical Formula: C11H12Cl2N2O5

Exact Mass:

Molecular Weight: 323.13

Elemental Analysis: C, 40.89; H, 3.74; Cl, 21.94; N, 8.67; O, 24.76

Price and Availability

This product was removed for the commercial reasons.
Related CAS #
No Data
Synonym
Chlordiazepoxide; Chlornitromycin; NSC 3069; Chloromycetin; Levomycetin; Chlorocid; Globenicol; Kloramfenikol; Levomycetin; Ophthochlor; Syntomycin;
IUPAC/Chemical Name
2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
InChi Key
WIIZWVCIJKGZOK-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)
SMILES Code
C1=CC(=CC=C1C(C(CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 323.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PubMed PMID: 26256248. 4: Feng X, Gan N, Zhang H, Yan Q, Li T, Cao Y, Hu F, Yu H, Jiang Q. A novel "dual-potential" electrochemiluminescence aptasensor array using CdS quantum dots and luminol-gold nanoparticles as labels for simultaneous detection of malachite green and chloramphenicol. Biosens Bioelectron. 2015 Dec 15;74:587-93. doi: 10.1016/j.bios.2015.06.048. Epub 2015 Jun 29. PubMed PMID: 26190470. 5: Franchino A, Jakubec P, Dixon DJ. Enantioselective synthesis of (-)-chloramphenicol via silver-catalysed asymmetric isocyanoacetate aldol reaction. Org Biomol Chem. 2015 Dec 15;14(1):93-96. PubMed PMID: 26510469. 6: Wang Y, Li X, Zhang Z, Ding S, Jiang H, Li J, Shen J, Xia X. Simultaneous determination of nitroimidazoles, benzimidazoles, and chloramphenicol components in bovine milk by ultra-high performance liquid chromatography-tandem mass spectrometry. Food Chem. 2016 Feb 1;192:280-7. doi: 10.1016/j.foodchem.2015.07.033. Epub 2015 Jul 8. PubMed PMID: 26304348. 7: Lu Y, Yao H, Li C, Han J, Tan Z, Yan Y. Separation, concentration and determination of trace chloramphenicol in shrimp from different waters by using polyoxyethylene lauryl ether-salt aqueous two-phase system coupled with high-performance liquid chromatography. Food Chem. 2016 Feb 1;192:163-70. doi: 10.1016/j.foodchem.2015.06.086. Epub 2015 Jul 3. PubMed PMID: 26304334. 8: Liu Y, Yan K, Okoth OK, Zhang J. A label-free photoelectrochemical aptasensor based on nitrogen-doped graphene quantum dots for chloramphenicol determination. Biosens Bioelectron. 2015 Dec 15;74:1016-21. doi: 10.1016/j.bios.2015.07.067. Epub 2015 Jul 30. PubMed PMID: 26264269. 9: Yan Z, Gan N, Wang D, Cao Y, Chen M, Li T, Chen Y. A "signal-on'' aptasensor for simultaneous detection of chloramphenicol and polychlorinated biphenyls using multi-metal ions encoded nanospherical brushes as tracers. Biosens Bioelectron. 2015 Dec 15;74:718-24. doi: 10.1016/j.bios.2015.07.024. Epub 2015 Jul 16. PubMed PMID: 26210469. 10: Abnous K, Danesh NM, Ramezani M, Emrani AS, Taghdisi SM. A novel colorimetric sandwich aptasensor based on an indirect competitive enzyme-free method for ultrasensitive detection of chloramphenicol. Biosens Bioelectron. 2015 Nov 12;78:80-86. doi: 10.1016/j.bios.2015.11.028. [Epub ahead of print] PubMed PMID: 26599477. 11: He J, Cui J. Malachite green and chloramphenicol in aquatic products from regions around Dongting Lake in Hunan, China. Food Addit Contam Part B Surveill. 2015 Nov 24:1-6. [Epub ahead of print] PubMed PMID: 26496159. 12: Yang T, Chen H, Ge T, Wang J, Li W, Jiao K. Highly sensitive determination of chloramphenicol based on thin-layered MoS2/polyaniline nanocomposite. Talanta. 2015 Nov 1;144:1324-8. doi: 10.1016/j.talanta.2015.08.004. Epub 2015 Aug 3. PubMed PMID: 26452965. 13: KuKanich B, KuKanich K. Chloramphenicol significantly affects the pharmacokinetics of oral methadone in Greyhound dogs. Vet Anaesth Analg. 2015 Nov;42(6):597-607. doi: 10.1111/vaa.12257. Epub 2015 Mar 2. PubMed PMID: 25733012. 14: Yan W, Yang L, Zhuang H, Wu H, Zhang J. Engineered "hot" core-shell nanostructures for patterned detection of chloramphenicol. Biosens Bioelectron. 2015 Nov 4;78:67-72. doi: 10.1016/j.bios.2015.11.011. [Epub ahead of print] PubMed PMID: 26594888. 15: Ebarvia BS, Ubando IE, Sevilla FB 3rd. Biomimetic piezoelectric quartz crystal sensor with chloramphenicol-imprinted polymer sensing layer. Talanta. 2015 Nov 1;144:1260-5. doi: 10.1016/j.talanta.2015.08.001. Epub 2015 Aug 6. PubMed PMID: 26452956. 16: Black LA, Higgins DP, Govendir M. In vitro activity of chloramphenicol, florfenicol and enrofloxacin against Chlamydia pecorum isolated from koalas (Phascolarctos cinereus). Aust Vet J. 2015 Nov;93(11):420-3. doi: 10.1111/avj.12364. Epub 2015 Sep 27. PubMed PMID: 26412342. 17: Thomseth V, Cejvanovic V, Jimenez-Solem E, Petersen KM, Poulsen HE, Andersen JT. Exposure to topical chloramphenicol during pregnancy and the risk of congenital malformations: a Danish nationwide cohort study. Acta Ophthalmol. 2015 Nov;93(7):651-3. doi: 10.1111/aos.12737. Epub 2015 Apr 28. PubMed PMID: 25923453. 18: Xiao Z, Song R, Rao Z, Wei S, Jia Z, Suo D, Fan X. Development of a subcritical water extraction approach for trace analysis of chloramphenicol, thiamphenicol, florfenicol, and florfenicol amine in poultry tissues. J Chromatogr A. 2015 Oct 30;1418:29-35. doi: 10.1016/j.chroma.2015.09.047. Epub 2015 Sep 24. PubMed PMID: 26433266. 19: Hao L, Duan N, Wu S, Xu B, Wang Z. Chemiluminescent aptasensor for chloramphenicol based on N-(4-aminobutyl)-N-ethylisoluminol-functionalized flower-like gold nanostructures and magnetic nanoparticles. Anal Bioanal Chem. 2015 Oct;407(26):7907-15. doi: 10.1007/s00216-015-8957-y. Epub 2015 Aug 22. PubMed PMID: 26297462. 20: Tan Z, Xu H, Li G, Yang X, Choi MM. 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Chlordimeform

Chlordimeform