MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 317328 | Name: Biperiden Hydrochloride
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Biperiden hydrochloride is a muscarinic antagonist that has effects in both the central and peripheral nervous systems. Biperiden Hydrochloride has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine.

Chemical Structure

Biperiden Hydrochloride
Biperiden Hydrochloride
CAS#1235-82-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 317328

Name: Biperiden Hydrochloride

CAS#: 1235-82-1 (HCl)

Chemical Formula: C21H30ClNO

Exact Mass: 0.0000

Molecular Weight: 347.92

Elemental Analysis: C, 72.49; H, 8.69; Cl, 10.19; N, 4.03; O, 4.60

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
25mg USD 650.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
1235-82-1 (HCl) 514-65-8 (free base) 7085-45-2 (lactate)
Synonym
Akineton; Akinophyl; Akineton hydrochloride; Biperiden; Biperiden Hydrochloride; Biperiden.
IUPAC/Chemical Name
1-(5-Bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidinyl)propan-1-ol hydrochloride
InChi Key
RDNLAULGBSQZMP-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H29NO.ClH/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17;/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2;1H
SMILES Code
C1CCN(CC1)CCC(C2CC3CC2C=C3)(C4=CC=CC=C4)O.Cl
Appearance
White to off-white solid powder.
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Biperiden Hydrochloride (KL 373 Hydrochloride) is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker.
In vitro activity:
Newly, this study described that biperiden (Bip) is a potent MALT1 inhibitor with even less pharmacological side effects. Thus, Bip is a promising drug leading to reduced proliferation and increased apoptosis in PDAC cells in vitro and in vivo. Reference: Int J Cancer. 2020 Mar 15;146(6):1618-1630. https://pubmed.ncbi.nlm.nih.gov/31291468/
In vivo activity:
Biperiden at different doses (1.0, 5.0, and 10.0 mg/kg) blocked the expression of ethanol-induced CPP in mice. These biperiden doses increased the number of Fos-positive cells and the dopamine turnover in the nucleus accumbens. None of the doses affected the motor coordination evaluated by the rotarod. Reference: Neurosci Lett. 2021 Feb 6;745:135551. https://pubmed.ncbi.nlm.nih.gov/33346074/
Solvent mg/mL mM comments
Solubility
DMSO 8.0 22.97
DMF 0.5 1.44
Ethanol 0.5 1.44
Water 3.4 9.69
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 347.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Konczalla L, Perez DR, Wenzel N, Wolters-Eisfeld G, Klemp C, Lüddeke J, Wolski A, Landschulze D, Meier C, Buchholz A, Yao D, Hofmann BT, Graß JK, Spriestersbach SL, Grupp K, Schumacher U, Betzel C, Kapis S, Nuguid T, Steinberg P, Püschel K, Sauter G, Bockhorn M, Uzunoglu FG, Izbicki JR, Güngör C, El Gammal AT. Biperiden and mepazine effectively inhibit MALT1 activity and tumor growth in pancreatic cancer. Int J Cancer. 2020 Mar 15;146(6):1618-1630. doi: 10.1002/ijc.32567. Epub 2019 Jul 25. PMID: 31291468. 2. Kostelnik A, Cegan A, Pohanka M. Anti-Parkinson Drug Biperiden Inhibits Enzyme Acetylcholinesterase. Biomed Res Int. 2017;2017:2532764. doi: 10.1155/2017/2532764. Epub 2017 Jul 13. PMID: 28785576; PMCID: PMC5530453. 3. Palombo P, Engi SA, Yokoyama TS, Bezerra AG, Curado DF, Anésio A, Leão RM, Santos PCJL, Cruz FC, Galduróz JCF. Effects of biperiden (cholinergic muscarinic m1/m4 receptor antagonist) on ethanol conditioned place preference in mice. Neurosci Lett. 2021 Feb 6;745:135551. doi: 10.1016/j.neulet.2020.135551. Epub 2020 Dec 17. PMID: 33346074. 4. Popelíková A, Bahník Š, Lobellová V, Svoboda J, Stuchlík A. Mnemonic and behavioral effects of biperiden, an M1-selective antagonist, in the rat. Psychopharmacology (Berl). 2018 Jul;235(7):2013-2025. doi: 10.1007/s00213-018-4899-3. Epub 2018 Apr 21. PMID: 29680966.
In vitro protocol:
1. Konczalla L, Perez DR, Wenzel N, Wolters-Eisfeld G, Klemp C, Lüddeke J, Wolski A, Landschulze D, Meier C, Buchholz A, Yao D, Hofmann BT, Graß JK, Spriestersbach SL, Grupp K, Schumacher U, Betzel C, Kapis S, Nuguid T, Steinberg P, Püschel K, Sauter G, Bockhorn M, Uzunoglu FG, Izbicki JR, Güngör C, El Gammal AT. Biperiden and mepazine effectively inhibit MALT1 activity and tumor growth in pancreatic cancer. Int J Cancer. 2020 Mar 15;146(6):1618-1630. doi: 10.1002/ijc.32567. Epub 2019 Jul 25. PMID: 31291468. 2. Kostelnik A, Cegan A, Pohanka M. Anti-Parkinson Drug Biperiden Inhibits Enzyme Acetylcholinesterase. Biomed Res Int. 2017;2017:2532764. doi: 10.1155/2017/2532764. Epub 2017 Jul 13. PMID: 28785576; PMCID: PMC5530453.
In vivo protocol:
1. Palombo P, Engi SA, Yokoyama TS, Bezerra AG, Curado DF, Anésio A, Leão RM, Santos PCJL, Cruz FC, Galduróz JCF. Effects of biperiden (cholinergic muscarinic m1/m4 receptor antagonist) on ethanol conditioned place preference in mice. Neurosci Lett. 2021 Feb 6;745:135551. doi: 10.1016/j.neulet.2020.135551. Epub 2020 Dec 17. PMID: 33346074. 2. Popelíková A, Bahník Š, Lobellová V, Svoboda J, Stuchlík A. Mnemonic and behavioral effects of biperiden, an M1-selective antagonist, in the rat. Psychopharmacology (Berl). 2018 Jul;235(7):2013-2025. doi: 10.1007/s00213-018-4899-3. Epub 2018 Apr 21. PMID: 29680966.
1: Kayipmaz AE, Giray TA, Tasci SS, Tasci SS, Kavalci C, Kocalar UG. Acute dystonic reaction due to dexketoprofen trometamol. J Pak Med Assoc. 2015 Nov;65(11):1231-2. PubMed PMID: 26564300. 2: Affaticati A, Gerra ML, Amerio A, Inglese M, Antonioni MC, Marchesi C. The Controversial Case of Biperiden: From Prescription Drug to Drug of Abuse. J Clin Psychopharmacol. 2015 Dec;35(6):749-50. doi: 10.1097/JCP.0000000000000421. PubMed PMID: 26479221. 3: Karadağ H, Acar M, Özdel K. Aripiprazole Induced Acute Transient Bilateral Myopia: A Case Report. Balkan Med J. 2015 Apr;32(2):230-2. doi: 10.5152/balkanmedj.2015.15292. Epub 2015 Apr 1. PubMed PMID: 26167352; PubMed Central PMCID: PMC4432708. 4: Danielmeier C, Allen EA, Jocham G, Onur OA, Eichele T, Ullsperger M. Acetylcholine mediates behavioral and neural post-error control. Curr Biol. 2015 Jun 1;25(11):1461-8. doi: 10.1016/j.cub.2015.04.022. Epub 2015 May 7. PubMed PMID: 25959965. 5: Ota T, Miura I, Kanno-Nozaki K, Hoshino H, Horikoshi S, Fujimori H, Kanno T, Mashiko H, Yabe H. Effects of Shakuyaku-Kanzo-to on Extrapyramidal Symptoms During Antipsychotic Treatment: A Randomized, Open-Label Study. J Clin Psychopharmacol. 2015 Jun;35(3):304-7. doi: 10.1097/JCP.0000000000000312. PubMed PMID: 25839338. 6: Stocker L, Jellestad L, Jenewein J, Boettger S. Challenges in the management of delirium: a case of augmentation with donepezil following inadequate response and adverse effects with risperidone. Psychiatr Danub. 2015 Mar;27(1):64-6. PubMed PMID: 25751433. 7: Minár M, Valkovič P. Thyroid-induced worsening of parkinsonian tremor resistant to drugs and subthalamic nucleus deep brain stimulation. Case Rep Neurol Med. 2014;2014:489275. doi: 10.1155/2014/489275. Epub 2014 Dec 31. PubMed PMID: 25628904; PubMed Central PMCID: PMC4297626. 8: Desmarais JE, Beauclair L, Annable L, Bélanger MC, Kolivakis TT, Margolese HC. Effects of discontinuing anticholinergic treatment on movement disorders, cognition and psychopathology in patients with schizophrenia. Ther Adv Psychopharmacol. 2014 Dec;4(6):257-67. doi: 10.1177/2045125314553611. PubMed PMID: 25489477; PubMed Central PMCID: PMC4257986. 9: Sambeth A, Riedel WJ, Klinkenberg I, Kähkönen S, Blokland A. Biperiden selectively induces memory impairment in healthy volunteers: no interaction with citalopram. Psychopharmacology (Berl). 2015 Jun;232(11):1887-97. doi: 10.1007/s00213-014-3822-9. Epub 2014 Dec 4. PubMed PMID: 25466702. 10: Douros A, Bronder E, Andersohn F, Klimpel A, Thomae M, Sarganas G, Kreutz R, Garbe E. Drug-induced liver injury: results from the hospital-based Berlin Case-Control Surveillance Study. Br J Clin Pharmacol. 2015 Jun;79(6):988-99. doi: 10.1111/bcp.12565. PubMed PMID: 25444550; PubMed Central PMCID: PMC4456131. 11: Veselinović T, Vernaleken I, Janouschek H, Kellermann T, Paulzen M, Cumming P, Gründer G. Effects of anticholinergic challenge on psychopathology and cognition in drug-free patients with schizophrenia and healthy volunteers. Psychopharmacology (Berl). 2015 May;232(9):1607-17. doi: 10.1007/s00213-014-3794-9. Epub 2014 Nov 7. PubMed PMID: 25373869. 12: Maltese M, Martella G, Madeo G, Fagiolo I, Tassone A, Ponterio G, Sciamanna G, Burbaud P, Conn PJ, Bonsi P, Pisani A. Anticholinergic drugs rescue synaptic plasticity in DYT1 dystonia: role of M1 muscarinic receptors. Mov Disord. 2014 Nov;29(13):1655-65. doi: 10.1002/mds.26009. Epub 2014 Sep 4. PubMed PMID: 25195914; PubMed Central PMCID: PMC4216601. 13: Witkin JM, Overshiner C, Li X, Catlow JT, Wishart GN, Schober DA, Heinz BA, Nikolayev A, Tolstikov VV, Anderson WH, Higgs RE, Kuo MS, Felder CC. M1 and m2 muscarinic receptor subtypes regulate antidepressant-like effects of the rapidly acting antidepressant scopolamine. J Pharmacol Exp Ther. 2014 Nov;351(2):448-56. doi: 10.1124/jpet.114.216804. Epub 2014 Sep 3. PubMed PMID: 25187432. 14: Szczodry O, van der Staay FJ, Arndt SS. Modelling Alzheimer-like cognitive deficits in rats using biperiden as putative cognition impairer. Behav Brain Res. 2014 Nov 1;274:307-11. doi: 10.1016/j.bbr.2014.08.036. Epub 2014 Aug 24. PubMed PMID: 25160769. 15: Dieckmann LH, Ramos AC, Silva EA, Justo LP, Sabioni P, Frade IF, de Souza AL, Galduróz JC. Effects of biperiden on the treatment of cocaine/crack addiction: a randomised, double-blind, placebo-controlled trial. Eur Neuropsychopharmacol. 2014 Aug;24(8):1196-202. doi: 10.1016/j.euroneuro.2014.06.001. Epub 2014 Jun 12. PubMed PMID: 24974353. 16: Ghaffarlou M, Golzari SE, Nezami N. A large asymptomatic foreign body in larynx and trachea. Quant Imaging Med Surg. 2014 Jun;4(3):210-1. doi: 10.3978/j.issn.2223-4292.2014.04.01. PubMed PMID: 24914423; PubMed Central PMCID: PMC4032917. 17: Lertxundi U, Hernandez R, Albeniz JM, Echaburu SD, Ruiz B, García MG, Aguirre C. Possible interaction between letrozole and long-acting injectable zuclopenthixol. Nord J Psychiatry. 2015 Jan;69(1):79-80. doi: 10.3109/08039488.2014.915341. Epub 2014 May 16. PubMed PMID: 24831298. 18: Paraschakis A. Tackling negative symptoms of schizophrenia with memantine. Case Rep Psychiatry. 2014;2014:384783. doi: 10.1155/2014/384783. Epub 2014 Apr 10. PubMed PMID: 24818033; PubMed Central PMCID: PMC4003755. 19: Suzuki T, Mihara K, Nakamura A, Kagawa S, Nagai G, Nemoto K, Kondo T. Effects of genetic polymorphisms of CYP2D6, CYP3A5, and ABCB1 on the steady-state plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole, in Japanese patients with schizophrenia. Ther Drug Monit. 2014 Oct;36(5):651-5. doi: 10.1097/FTD.0000000000000070. PubMed PMID: 24682161. 20: Ramachandran S, Osterhaus SR, Karp PH, Welsh MJ, McCray PB Jr. A genomic signature approach to rescue ΔF508-cystic fibrosis transmembrane conductance regulator biosynthesis and function. Am J Respir Cell Mol Biol. 2014 Sep;51(3):354-62. doi: 10.1165/rcmb.2014-0007OC. PubMed PMID: 24669817; PubMed Central PMCID: PMC4189493.