AZD-5122 (also known as SRT3109) is a potent and selective CXCR2 (CXC chemokine receptor 2) antagonist under investigation for inflammatory diseases. It exhibits strong affinity for human CXCR2, with an IC₅₀ of approximately 3.4 nM in cell-based calcium flux assays using neutrophils. AZD-5122 demonstrates robust inhibition of CXCL1-induced neutrophil migration (IC₅₀ ~5.1 nM) and blocks downstream signaling such as ERK phosphorylation. In preclinical animal models, AZD-5122 effectively reduced neutrophilic infiltration in inflamed tissues, confirming its anti-inflammatory potential. The compound has entered early-phase clinical trials to assess its pharmacokinetics, safety, and efficacy in diseases like chronic obstructive pulmonary disease (COPD).
MedKoo Cat#: 522511
Name: AZD-5122 free base
CAS#: 1204707-71-0 (free base)
Chemical Formula: C18H23F2N5O4S2
Exact Mass: 475.1160
Molecular Weight: 475.53
Elemental Analysis: C, 45.46; H, 4.88; F, 7.99; N, 14.73; O, 13.46; S, 13.48
The following data is based on the product molecular weight 475.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
