MedKoo Cat#: 317316 | Name: Benzthiazide
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Benzthiazide is a research compound with diuretic and antihypertensive properties used in the treatment of high blood pressure and edema.

Chemical Structure

Benzthiazide
CAS#91-33-8

Theoretical Analysis

MedKoo Cat#: 317316

Name: Benzthiazide

CAS#: 91-33-8

Chemical Formula: C15H14ClN3O4S3

Exact Mass: 430.9835

Molecular Weight: 431.94

Elemental Analysis: C, 41.71; H, 3.27; Cl, 8.21; N, 9.73; O, 14.82; S, 22.27

Price and Availability

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500mg USD 350.00 2 Weeks
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Synonym
Benzthiazide; Benzothiazide; Dihydrex; Aquatag; Diucen; Exna; Edemax; Foven; Dytide
IUPAC/Chemical Name
3-[(benzylsulfanyl)methyl]-6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
InChi Key
NDTSRXAMMQDVSW-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H14ClN3O4S3/c16-11-6-12-14(7-13(11)25(17,20)21)26(22,23)19-15(18-12)9-24-8-10-4-2-1-3-5-10/h1-7H,8-9H2,(H,18,19)(H2,17,20,21)
SMILES Code
O=S(C1=C(Cl)C=C(C2=C1)NC(CSCC3=CC=CC=C3)=NS2(=O)=O)(N)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 431.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Adler RA, Costanzo LS, Stauffer ME. Hypercalciuria in hyperprolactinemic rats: effects of benzthiazide. Metabolism. 1986 Jul;35(7):668-72. PubMed PMID: 3724459. 2: Shah VP, Keys CA, King DM, Prasad VK, Cabana BE. Thiazides XIII: Dissolution testing: a bioavailability predictor for benzthiazide tablets. Biopharm Drug Dispos. 1982 Jul-Sep;3(3):283-5. PubMed PMID: 7139068. 3: Meyer MC, Hwang P, Straughn AB, Rotenberg K. HPLC determination of benzthiazide in biologic material. Biopharm Drug Dispos. 1982 Jan-Mar;3(1):1-9. PubMed PMID: 7082774. 4: Yajnik VH, Doshi HV, Patel SC, Doshi KJ. Combined treatment with triamterene and benzthiazide in cases of hypertension. J Assoc Physicians India. 1977 Jan;25(1):31-6. PubMed PMID: 924952. 5: Fazzari FR. Collaborative study of assay for benzthiazide and hydrochlorothiazide in pharmaceuticals. J Assoc Off Anal Chem. 1972 Jan;55(1):161-2. PubMed PMID: 4666837. 6: Shah CP, Shah BR, Sanghavi NG, Shah JB, Trivedi PM. Treatment of oedema with a combination of triamterene with benzthiazide. J Assoc Physicians India. 1969 Oct;17(10):605-13. PubMed PMID: 5344774. 7: Thomas J, Thomas E, Desgrez P. [Association of phytic acid and benzthiazide in renal lithiasis]. Rein Foie. 1966;8:171-85. French. PubMed PMID: 5914037. 8: Gylding-Sabroe JP, Borch Nielsen H. [Triamterene and benzthiazide in long-term treatment of edemas]. Nord Med. 1965 Nov 25;74(47):1195-8. Danish. PubMed PMID: 5848420. 9: Thomas J, Thomas E, Desgrez P. [Hypocalciuric action of benzthiazide evaluated on 50 cases of hypercalciuric renal lithiasis. Concomitant study of phosphate, magnesium and urate elimination and of the behavior of titratable acidity and urinary pH]. Therapie. 1965 Nov-Dec;20(6):1443-61. French. PubMed PMID: 5855992. 10: Thompson RA, Crowley MF. Trial of a triamterene-benzthiazide combination (Dytide). Postgrad Med J. 1965 Nov;41(481):706-11. PubMed PMID: 5320489; PubMed Central PMCID: PMC2483201. 11: EDGE JR, ADISESH LT. COMBINED BENZTHIAZIDE AND TRIAMTERENE FOR RESISTANT EDEMA. Appl Ther. 1965 Feb;7:117-9. PubMed PMID: 14264860. 12: TOURNIAIRE A, BLUM J, GUYOT R. [EFFECT OF THE MICRONIZED SPIRONOLACTONE-BENZTHIAZIDE ASSOCIATION ON CONGESTIVE CARDIAC INSUFFICIENCY. TEST OF CONTINUOUS TREATMENT]. Lyon Med. 1964 Nov 22;212:1159-80. French. PubMed PMID: 14233310. 13: SOULIE P, COLONNA D. [THE BENZTHIAZIDE-TRIAMTERENE COMBINATION. CLINICAL EXPERIMENTATION IN CARDIOLOGY]. Arch Mal Coeur Vaiss. 1964 Aug;57:942-52. French. PubMed PMID: 14192889. 14: HOLT MC. USE OF METHOSERPIDINE-BENZTHIAZIDE COMBINATION IN THE TREATMENT OF ESSENTIAL HYPERTENSION. Br J Clin Pract. 1964 Apr;19:199-204. PubMed PMID: 14272419. 15: WAREMBOURG H, BASIN B. [CLINICAL AND BIOLOGICAL STUDY OF A DIURETIC PREPARATION COMBINING TRIAMINOPTERIDINE AND BENZTHIAZIDE]. Lille Med. 1964 Mar;37:277-84. French. PubMed PMID: 14141055. 16: DELAHAYE JP, VALLON C, PELLET M, GONIN A. [THERAPEUTIC TRIAL OF TRIAMTERENE AND TRIAMTERENE-BENZTHIAZIDE IN CARDIOLOGY]. J Med Lyon. 1964 Jan 20;45:185-92. French. PubMed PMID: 14113141. 17: POTTON F, DESSIMOND JL. [HYPOCALCIURIC EFFECT OF BENZTHIAZIDE]. Lyon Med. 1963 Nov 24;210:1043-72. French. PubMed PMID: 14099113. 18: MIROUZE J, JAFFIOL C. [IMPORTANCE OF BENZTHIAZIDE, AN ORIGINAL SULFONAMIDE DIURETIC]. Gaz Med Fr. 1963 Sep 25;70:2765-9. French. PubMed PMID: 14121074. 19: GOLASZEWSKI J, HEALY JM. A clinical evaluation of a combination of two oral diuretics--triamterene and benzthiazide. Br J Dis Chest. 1963 Jan;57:53-8. PubMed PMID: 13948632. 20: DIEBOLD A, CAPDEVILLE R. [Arterial hypertension. Clinical experimentation with a new hypotensive comination: 10-methoxydeserpidine-benzthiazide-potassium chloride]. Presse Med. 1962 Dec 22;70:2703-4. French. PubMed PMID: 14027747.