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MedKoo Cat#: 317259 | Name: Atracurium Besylate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Atracurium Besilate is a neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Atracurium is classified as an intermediate-duration non-depolarizing neuromuscular-blocking agent.

Chemical Structure

Atracurium Besylate
Atracurium Besylate
CAS#64228-81-5 (besylate_mixture of isomers)

Theoretical Analysis

MedKoo Cat#: 317259

Name: Atracurium Besylate

CAS#: 64228-81-5 (besylate_mixture of isomers)

Chemical Formula: C59H78N2O15S2+

Exact Mass: 0.0000

Molecular Weight: 1087.32

Elemental Analysis: C, 65.17; H, 7.23; N, 2.58; O, 22.07; S, 2.95

Price and Availability

Size Price Availability Quantity
500mg USD 250.00 2 Weeks
1g USD 450.00 2 Weeks
2g USD 750.00 2 Weeks
5g USD 1,450.00 2 Weeks
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Related CAS #
64228-81-5 (besylate_mixture of isomers) 96946-41-7 (free base) 96946-42-8 (besylate)
Synonym
33A74; Atracurium; Atracurium Besilate; Atracurium Besylate; Atracurium Dibesylate; Besilate, Atracurium; BW 33A; BW-33A; BW33A; Glaxo Wellcome Brand of Atracurium Besilate; Pisa Brand of Atracurium Besilate; Relatrac; Tracrium; Wellcome Brand of Atracurium Besilate
IUPAC/Chemical Name
benzenesulfonate;5-[3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl 3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate
InChi Key
KTFFUISFKXNFHH-UHFFFAOYSA-N
InChi Code
InChI=1S/C53H72N2O12.C6H6O3S/c1-12-13-14-27-66-50(56)21-25-55(3)24-20-38-40(42(55)29-36-16-18-44(59-5)46(31-36)61-7)34-49(64-10)53(65-11)52(38)67-51(57)22-26-54(2)23-19-37-32-47(62-8)48(63-9)33-39(37)41(54)28-35-15-17-43(58-4)45(30-35)60-6;7-10(8,9)6-4-2-1-3-5-6/h15-18,30-34,41-42H,12-14,19-29H2,1-11H3;1-5H,(H,7,8,9)/q+2;
SMILES Code
O=C(OCCCCC)CC[N+]1(C)C(CC2=CC=C(OC)C(OC)=C2)C3=C(C(OC(CC[N+]4(C)C(CC5=CC=C(OC)C(OC)=C5)C6=C(C=C(OC)C(OC)=C6)CC4)=O)=C(OC)C(OC)=C3)CC1.O=S(C7=CC=CC=C7)(O)=O
Appearance
Solid powder
Purity
>98% (mixture of isomers)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,087.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ramaswamy AH, Kurdi MS, Sindhupriya. TIVA-A Promising Approach to Anaesthetic Management of Montgomery T-tube Insertion. J Clin Diagn Res. 2015 Aug;9(8):UD03-4. doi: 10.7860/JCDR/2015/13563.6395. Epub 2015 Aug 1. PubMed PMID: 26436024; PubMed Central PMCID: PMC4576618. 2: Pandey RK, Subramanium RK, Darlong V, Lekha C, Garg R, Punj J, Rewari V, Bajpai M. Evaluation of glottic view through Air-Q Intubating Laryngeal Airway in the supine and lateral position and assessing it as a conduit for blind endotracheal intubation in children in the supine position. Paediatr Anaesth. 2015 Dec;25(12):1241-7. doi: 10.1111/pan.12746. Epub 2015 Sep 29. PubMed PMID: 26417722. 3: Batistaki C, Tentes P, Deligiannidi P, Karakosta A, Florou P, Kostopanagiotou G. Residual neuromuscular blockade in a real life clinical setting. Correlation with sugammadex or neostigmine administration. Minerva Anestesiol. 2015 Sep 22. [Epub ahead of print] PubMed PMID: 26394365. 4: Jain D, Ghai B, Bala I, Gandhi K, Banerjee G. Evaluation of I-gel(™) airway in different head and neck positions in anesthetized paralyzed children. Paediatr Anaesth. 2015 Dec;25(12):1248-53. doi: 10.1111/pan.12748. Epub 2015 Sep 18. PubMed PMID: 26383088. 5: Sudré EC, de Batista PR, Castiglia YM. Longer Immediate Recovery Time After Anesthesia Increases Risk of Respiratory Complications After Laparotomy for Bariatric Surgery: a Randomized Clinical Trial and a Cohort Study. Obes Surg. 2015 Nov;25(11):2205-12. doi: 10.1007/s11695-015-1855-8. PubMed PMID: 26374138. 6: Locks Gde F, Cavalcanti IL, Duarte NM, da Cunha RM, de Almeida MC. Use of neuromuscular blockers in Brazil. Braz J Anesthesiol. 2015 Sep-Oct;65(5):319-25. doi: 10.1016/j.bjane.2015.03.001. Epub 2015 Aug 15. PubMed PMID: 26323727. 7: Yoo YC, Kim NY, Shin S, Choi YD, Hong JH, Kim CY, Park H, Bai SJ. The Intraocular Pressure under Deep versus Moderate Neuromuscular Blockade during Low-Pressure Robot Assisted Laparoscopic Radical Prostatectomy in a Randomized Trial. PLoS One. 2015 Aug 28;10(8):e0135412. doi: 10.1371/journal.pone.0135412. eCollection 2015. PubMed PMID: 26317357; PubMed Central PMCID: PMC4552736. 8: Dewachter P, Mouton-Faivre C. Anaphylaxis incidence with rocuronium, succinylcholine, and atracurium: how risk communication can influence behavior. Anesthesiology. 2015 Sep;123(3):735-6. doi: 10.1097/ALN.0000000000000775. PubMed PMID: 26284871. 9: Darlong V, Garg R, Pandey R, Khokhar S, Chandralekha, Sinha R, Punj J, Sinha R. Evaluation of minimal dose of atracurium for cataract surgery in children: A prospective randomized double-blind study. Saudi J Anaesth. 2015 Jul-Sep;9(3):283-8. doi: 10.4103/1658-354X.154711. PubMed PMID: 26240547; PubMed Central PMCID: PMC4478821. 10: Locks Gde F, Cavalcanti IL, Duarte NM, Cunha RM, Almeida MC. [Use of neuromuscular blockers in Brazil]. Rev Bras Anestesiol. 2015 Sep-Oct;65(5):319-25. doi: 10.1016/j.bjan.2015.03.001. Epub 2015 Jul 6. Portuguese. PubMed PMID: 26160168. 11: Dębska M, Szymkiewicz-Dangel J, Koleśnik A, Kretowicz P, Rebizant B, Witwicki J, Dębski R. [Fetal cardiac interventions - are we ready for them?]. Ginekol Pol. 2015 Apr;86(4):280-6. Polish. PubMed PMID: 26117987. 12: Marshall SD, Boden E, Serpell J. The effect of routine reversal of neuromuscular blockade on adequacy of recurrent laryngeal nerve stimulation during thyroid surgery. Anaesth Intensive Care. 2015 Jul;43(4):485-9. PubMed PMID: 26099761. 13: Refaat AI, Hedaya MS, Ezzat HM, Fayed MM, Salama AF, Helmy AH. Randomized clinical trial comparing two different techniques of local anesthesia (subcutaneous versus subcutaneous & deep infiltration) for postoperative pain in patients undergoing open appendecectomy. J Egypt Soc Parasitol. 2015 Apr;45(1):177-82. PubMed PMID: 26012232. 14: Zuche H, Morinello E, Viestenz A, Fiorentzis MF, Volk T, Seitz B, Viestenz A. [The Effect of Non-Depolarising Muscle Relaxants on Ocular Pulse Amplitude and Intraocular Pressure]. Klin Monbl Augenheilkd. 2015 May 21. [Epub ahead of print] German. PubMed PMID: 25997093. 15: Galluzzi F, De Rensis F, Saleri R, Spattini G. Effect of urethral infusion of atracurium besylate on manual bladder expression in dogs and cats with spinal cord injuries: a randomised trial. Vet Rec. 2015 May 23;176(21):545. doi: 10.1136/vr.102825. Epub 2015 Apr 28. PubMed PMID: 25920417. 16: Berroa F, Lafuente A, Javaloyes G, Cabrera-Freitag P, de la Borbolla JM, Moncada R, Goikoetxea MJ, Sanz ML, Ferrer M, Gastaminza G. The incidence of perioperative hypersensitivity reactions: a single-center, prospective, cohort study. Anesth Analg. 2015 Jul;121(1):117-23. doi: 10.1213/ANE.0000000000000776. PubMed PMID: 25902325. 17: Das W, Bhattacharya S, Ghosh S, Saha S, Mallik S, Pal S. Comparison between general anesthesia and spinal anesthesia in attenuation of stress response in laparoscopic cholecystectomy: A randomized prospective trial. Saudi J Anaesth. 2015 Apr-Jun;9(2):184-8. doi: 10.4103/1658-354X.152881. PubMed PMID: 25829908; PubMed Central PMCID: PMC4374225. 18: Banerjee A, Das B, Mukherjee D, Khanra M. A study of the effect of caudal epidural block on bispectral index targeted propofol requirement in children: A comparative study. J Indian Assoc Pediatr Surg. 2015 Apr-Jun;20(2):77-81. doi: 10.4103/0971-9261.151551. PubMed PMID: 25829671; PubMed Central PMCID: PMC4360459. 19: Eftekhari J, Kazemi Haki B, Tizro P, Alizadeh V. A comparison to facilitate insertion of the laryngeal mask: term of recovery and postoperative nausea and vomiting after anesthesia with propofol- atracurium and thiopental-atracurium. Acta Med Iran. 2015;53(2):117-21. PubMed PMID: 25725181. 20: Patel TK, Patel PB, Barvaliya MJ, Tripathi CB. Drug-induced anaphylactic reactions in Indian population: A systematic review. Indian J Crit Care Med. 2014 Dec;18(12):796-806. doi: 10.4103/0972-5229.146313. PubMed PMID: 25538414; PubMed Central PMCID: PMC4271279.