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MedKoo Cat#: 317144 | Name: Tizoxanide
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tizoxanide is the active metabolite of nitazoxanide, an anti-infective that has been approved for the treatment of diarrhea caused by Giardia lamblia or Crytosporidium parvum. Tizoxanide is active against anaerobic bacteria, protozoan parasites, and viruses. Tizoxanide is a potent inhibitor of hepatitis B virus and hepatitis C virus replication.

Chemical Structure

Tizoxanide
Tizoxanide
CAS#173903-47-4

Theoretical Analysis

MedKoo Cat#: 317144

Name: Tizoxanide

CAS#: 173903-47-4

Chemical Formula: C10H7N3O4S

Exact Mass: 265.0157

Molecular Weight: 265.24

Elemental Analysis: C, 45.28; H, 2.66; N, 15.84; O, 24.13; S, 12.09

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 2 Weeks
100mg USD 650.00 2 Weeks
200mg USD 950.00 2 Weeks
500mg USD 1,950.00 2 Weeks
1g USD 2,950.00 2 Weeks
2g USD 4,650.00 2 Weeks
5g USD 6,950.00 2 Weeks
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Related CAS #
No Data
Synonym
NSC-697856; NSC697856; NSC697856; Tizoxanide; Desacetylnitazoxanide; Desacetyl-nitazoxanide.
IUPAC/Chemical Name
2-hydroxy-N-(5-nitrothiazol-2-yl)benzamide
InChi Key
FDTZUTSGGSRHQF-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H7N3O4S/c14-7-4-2-1-3-6(7)9(15)12-10-11-5-8(18-10)13(16)17/h1-5,14H,(H,11,12,15)
SMILES Code
O=C(NC1=NC=C([N+]([O-])=O)S1)C2=CC=CC=C2O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 265.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yamamoto KA, Blackburn K, Goshe MB, Brown DT, Migoswski E, Campanhon IB, Moreira MF, Ferreira DF, Soares MR. Tizoxanide Antiviral Activity on Dengue Virus Replication. Viruses. 2023 Mar 7;15(3):696. doi: 10.3390/v15030696. PMID: 36992406; PMCID: PMC10055917. 2: Ni B, Yan J, Cai W, Xiao Y, Tu C. Tizoxanide as a novel theraputic candidate for osteoarthritis. Heliyon. 2023 Aug 26;9(9):e19472. doi: 10.1016/j.heliyon.2023.e19472. PMID: 37662752; PMCID: PMC10472306. 3: Zheng H, Deng H, Chen Y, Li D. Tizoxanide pyridine monosolvate. Acta Crystallogr Sect E Struct Rep Online. 2012 May 1;68(Pt 5):o1453-4. doi: 10.1107/S1600536812016133. Epub 2012 Apr 21. PMID: 22590331; PMCID: PMC3344569. 4: Shou J, Kong X, Wang X, Tang Y, Wang C, Wang M, Zhang L, Liu Y, Fei C, Xue F, Li J, Zhang K. Tizoxanide Inhibits Inflammation in LPS-Activated RAW264.7 Macrophages via the Suppression of NF-κB and MAPK Activation. Inflammation. 2019 Aug;42(4):1336-1349. doi: 10.1007/s10753-019-00994-3. PMID: 30937840. 5: Huang S, Xiao J, Wu J, Liu J, Feng X, Yang C, Xiang D, Luo S. Tizoxanide Promotes Apoptosis in Glioblastoma by Inhibiting CDK1 Activity. Front Pharmacol. 2022 May 25;13:895573. doi: 10.3389/fphar.2022.895573. PMID: 35694267; PMCID: PMC9174573. 6: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. Nitazoxanide. 2023 Sep 15. PMID: 29999627. 7: He X, Hu W, Meng F, Li X. Design, Synthesis, and Pharmacokinetic Evaluation of O-Carbamoyl Tizoxanide Prodrugs. Med Chem. 2022;18(1):140-150. doi: 10.2174/1573406416666201120102905. PMID: 33222677. 8: Neary M, Arshad U, Tatham L, Pertinez H, Box H, Rajoli RKR, Valentijn A, Sharp J, Rannard SP, Biagini GA, Curley P, Owen A. Quantitation of tizoxanide in multiple matrices to support cell culture, animal and human research. J Chromatogr B Analyt Technol Biomed Life Sci. 2023 Aug 1;1228:123823. doi: 10.1016/j.jchromb.2023.123823. Epub 2023 Jul 16. PMID: 37517355. 9: Guo S, Li F, Wang B, Zhao Y, Wang X, Wei H, Yu K, Hai X. Analysis of tizoxanide, active metabolite of nitazoxanide, in rat brain tissue and plasma by UHPLC-MS/MS. Biomed Chromatogr. 2020 Feb;34(2):e4716. doi: 10.1002/bmc.4716. Epub 2019 Dec 2. PMID: 31633824. 10: Shou J, Wang M, Cheng X, Wang X, Zhang L, Liu Y, Fei C, Wang C, Gu F, Xue F, Li J, Zhang K. Tizoxanide induces autophagy by inhibiting PI3K/Akt/mTOR pathway in RAW264.7 macrophage cells. Arch Pharm Res. 2020 Feb;43(2):257-270. doi: 10.1007/s12272-019-01202-4. Epub 2020 Jan 1. Erratum in: Arch Pharm Res. 2020 Feb;43(2):271. doi: 10.1007/s12272-020-01210-9. PMID: 31894502.

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