Synonym
TM5007; TM-5007; TM 5007
IUPAC/Chemical Name
5',5'''-(adipoylbis(azanediyl))bis(([2,3'-bithiophene]-4'-carboxylic acid))
InChi Key
USLUSWIVVBUXLU-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H20N2O6S4/c27-17(25-21-19(23(29)30)13(11-35-21)15-5-3-9-33-15)7-1-2-8-18(28)26-22-20(24(31)32)14(12-36-22)16-6-4-10-34-16/h3-6,9-12H,1-2,7-8H2,(H,25,27)(H,26,28)(H,29,30)(H,31,32)
SMILES Code
O=C(NC1=C(C(O)=O)C(C2=CC=CS2)=CS1)CCCCC(NC3=C(C(O)=O)C(C4=CC=CS4)=CS3)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
560.67
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Yamaoka N, Kawano Y, Izuhara Y, Miyata T, Meguro K. Structure-activity
relationships of new 2-acylamino-3-thiophenecarboxylic acid dimers as
plasminogen activator inhibitor-1 inhibitors. Chem Pharm Bull (Tokyo). 2010
May;58(5):615-9. doi: 10.1248/cpb.58.615. PMID: 20460785.
2: Izuhara Y, Takahashi S, Nangaku M, Takizawa S, Ishida H, Kurokawa K, van
Ypersele de Strihou C, Hirayama N, Miyata T. Inhibition of plasminogen activator
inhibitor-1: its mechanism and effectiveness on coagulation and fibrosis.
Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):672-7. doi:
10.1161/ATVBAHA.107.157479. Epub 2008 Jan 31. PMID: 18239154.
3: Izuhara Y, Yamaoka N, Kodama H, Dan T, Takizawa S, Hirayama N, Meguro K, van
Ypersele de Strihou C, Miyata T. A novel inhibitor of plasminogen activator
inhibitor-1 provides antithrombotic benefits devoid of bleeding effect in
nonhuman primates. J Cereb Blood Flow Metab. 2010 May;30(5):904-12. doi:
10.1038/jcbfm.2009.272. Epub 2010 Jan 20. PMID: 20087372; PMCID: PMC2949193.
