MedKoo Cat#: 317154 | Name: Aceprometazine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aceprometazine (INN) is a prescription drug with neuroleptic and anti-histamine properties. It may be used in combination with meprobamate for the treatment of sleep disorders. This combination is available in France under the trade name Mepronizine.

Chemical Structure

Aceprometazine
Aceprometazine
CAS#13461-01-3 (free)

Theoretical Analysis

MedKoo Cat#: 317154

Name: Aceprometazine

CAS#: 13461-01-3 (free)

Chemical Formula: C19H22N2OS

Exact Mass: 326.1453

Molecular Weight: 326.46

Elemental Analysis: C, 69.90; H, 6.79; N, 8.58; O, 4.90; S, 9.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
13461-01-3 (free) 7455-18-7 (maleate)
Synonym
Mepronizine; Acepromethazine; Aceprometazine; Aceprometazina; Aceprometazinum; Aceprometazinum; Aceprometazina .
IUPAC/Chemical Name
1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]ethanone
InChi Key
XLOQNFNTQIRSOX-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H22N2OS/c1-13(20(3)4)12-21-16-7-5-6-8-18(16)23-19-10-9-15(14(2)22)11-17(19)21/h5-11,13H,12H2,1-4H3
SMILES Code
CC(CN1C2=CC=CC=C2SC3=C1C=C(C=C3)C(=O)C)N(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 326.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zaïem A, Kaabi W, Badri T, Lakhoua G, Sahnoun R, Kastalli S, Daghfous R, Lakhal M, El Aidli S. Meprobamate-induced fixed drug eruption. Curr Drug Saf. 2014;9(2):161-2. PubMed PMID: 24446836. 2: Mounier B, Pons B, Delavenne X, Beyens MN, Rémy C, Zeni F, Mismetti P, Basset T. [Severe meprobamate poisoning: description of 146 cases in a French department]. Therapie. 2012 Mar-Apr;67(2):183-9. doi: 10.2515/therapie/2012019. Epub 2012 Aug 2. French. PubMed PMID: 22850107. 3: Pélissier-Alicot AL, Piercecchi-Marti MD, Bartoli C, Kuhlmann E, Coiffait PE, Sanvoisin A, Giocanti D, Léonetti G. Abusive prescription of psychostimulants: a study of two cases. J Forensic Sci. 2006 Mar;51(2):407-10. PubMed PMID: 16566781. 4: Lapostolle F, Finot MA, Adnet F, Borron SW, Baud FJ, Bismuth C. Radiopacity of clomipramine conglomerations and unsuccessful endoscopy: report of 4 cases. J Toxicol Clin Toxicol. 2000;38(5):477-82. PubMed PMID: 10981957. 5: Cherin P, Colvez A, Deville de Periere G, Sereni D. Risk of syncope in the elderly and consumption of drugs: a case-control study. J Clin Epidemiol. 1997 Mar;50(3):313-20. PubMed PMID: 9120531. 6: Mercier J, Dessaigne S, Menguy A, Manez J. Electro-encephalographic study on the action of the combination meprobamate-aceprometazine on various cerebral systems. Arzneimittelforschung. 1974 Feb;24(2):163-6. PubMed PMID: 4406367.