VU0483605 | CAS#1623101-11-0 | mGluR1

MedKoo Cat#: 522454 | Name: VU0483605

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

VU0483605 is a potent and selective positive allosteric modulator (PAM) of mGluR1, displaying EC50 values of 0.39 and 0.36 μM at human and rat receptors, respectively, and no activity as a mGlu4 PAM (EC50 >10 μM).

Chemical Structure

VU0483605

CAS#1623101-11-0

Theoretical Analysis

MedKoo Cat#: 522454

Name: VU0483605

CAS#: 1623101-11-0

Chemical Formula: C20H10Cl3N3O3

Exact Mass: 444.9788

Molecular Weight: 446.67

Elemental Analysis: C, 53.78; H, 2.26; Cl, 23.81; N, 9.41; O, 10.75

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 400.00
10mg	USD 650.00

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Related CAS #

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Synonym

VU0483605, VU-0483605, VU 048360

IUPAC/Chemical Name

3-chloro-N-[3-chloro-4-(4-chloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-2-pyridinecarboxamide

InChi Key

HJQXPBKPTGWZCF-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H10Cl3N3O3/c21-12-4-1-3-11-16(12)20(29)26(19(11)28)15-7-6-10(9-14(15)23)25-18(27)17-13(22)5-2-8-24-17/h1-9H,(H,25,27)

SMILES Code

O=C(C1=NC=CC=C1Cl)NC2=CC=C(N(C(C3=C4C=CC=C3Cl)=O)C4=O)C(Cl)=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 446.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Cavallo, D., Landucci, E., Gerace, E., Lana, D., Ugolini, F., Henley, J. M., ... & Pellegrini-Giampietro, D. E. (2020). Neuroprotective effects of mGluR5 activation through the PI3K/Akt pathway and the molecular switch of AMPA receptors. Neuropharmacology, 162, 107810. Cho, H. P., Garcia-Barrantes, P. M., Brogan, J. T., Hopkins, C. R., Niswender, C. M., Rodriguez, A. L., ... & Lindsley, C. W. (2014). Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics. ACS chemical biology, 9(10), 2334-2346. Garcia-Barrantes, P. M., Cho, H. P., Blobaum, A. L., Niswender, C. M., Conn, P. J., & Lindsley, C. W. (2015). Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 1: SAR of modifications to the central aryl core. Bioorganic & medicinal chemistry letters, 25(22), 5107-5110. Garcia Barrantes, P. M. (2016). Total synthesis of Gombamide A and Actinophenanthroline A. Discovery, optimization and characterization of novel positive allosteric modulators for the metabotropic glutamate receptor subtype 1 (Doctoral dissertation).