A412997 | CAS#630116-49-3 | D4R agonist

MedKoo Cat#: 531354 | Name: A412997

Description:

WARNING: This product is for research use only, not for human or veterinary use.

A412997 is a selective D4R agonist. -412997 showed significant dose-dependent efficacy in both models. A-412997 binds with high affinity to rat dopamine D4 and human dopamine D4.4 receptors (Ki=12.1 and 7.9 nM, respectively). In contrast to the dopamine D4 receptor agonists PD168077 and CP226269, A-412997 showed a better selectivity profile and no affinity <1000 nM for other dopamine receptors or any other proteins in a panel of seventy different receptors and channels. In functional assays using calcium flux, A-412997 was a potent full agonist at rat dopamine D4 receptors (28.4 nM, intrinsic activity=0.83) and did not activate rat dopamine D2L receptors.

Chemical Structure

A412997

CAS#630116-49-3

Theoretical Analysis

MedKoo Cat#: 531354

Name: A412997

CAS#: 630116-49-3

Chemical Formula: C19H23N3O

Exact Mass: 309.1841

Molecular Weight: 309.41

Elemental Analysis: C, 73.76; H, 7.49; N, 13.58; O, 5.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

A412997; A-412997; A 412997;

IUPAC/Chemical Name

N-(3-methylphenyl)-2-(4-pyridin-2-ylpiperidin-1-yl)acetamide

InChi Key

JFCDMGGMCUKHST-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H23N3O/c1-15-5-4-6-17(13-15)21-19(23)14-22-11-8-16(9-12-22)18-7-2-3-10-20-18/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,21,23)

SMILES Code

O=C(NC1=CC=CC(C)=C1)CN2CCC(C3=NC=CC=C3)CC2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 309.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Thörn CW, Kafetzopoulos V, Kocsis B. Differential Effect of Dopamine D4 Receptor Activation on Low-Frequency Oscillations in the Prefrontal Cortex and Hippocampus May Bias the Bidirectional Prefrontal-Hippocampal Coupling. Int J Mol Sci. 2022 Oct 3;23(19):11705. doi: 10.3390/ijms231911705. PMID: 36233007; PMCID: PMC9569525. 2: Hui Y, Du C, Xu T, Zhang Q, Tan H, Liu J. Dopamine D4 receptors in the lateral habenula regulate depression-related behaviors via a pre-synaptic mechanism in experimental Parkinson's disease. Neurochem Int. 2020 Nov;140:104844. doi: 10.1016/j.neuint.2020.104844. Epub 2020 Sep 3. PMID: 32891683. 3: Keck TM, Free RB, Day MM, Brown SL, Maddaluna MS, Fountain G, Cooper C, Fallon B, Holmes M, Stang CT, Burkhardt R, Bonifazi A, Ellenberger MP, Newman AH, Sibley DR, Wu C, Boateng CA. Dopamine D4 Receptor-Selective Compounds Reveal Structure-Activity Relationships that Engender Agonist Efficacy. J Med Chem. 2019 Apr 11;62(7):3722-3740. doi: 10.1021/acs.jmedchem.9b00231. Epub 2019 Apr 1. PMID: 30883109; PMCID: PMC6466480. 4: Real JI, Simões AP, Cunha RA, Ferreira SG, Rial D. Adenosine A2A receptors modulate the dopamine D2 receptor-mediated inhibition of synaptic transmission in the mouse prefrontal cortex. Eur J Neurosci. 2018 May;47(9):1127-1134. doi: 10.1111/ejn.13912. Epub 2018 Apr 2. PMID: 29570875. 5: Furth KE, McCoy AJ, Dodge C, Walters JR, Buonanno A, Delaville C. Neuronal correlates of ketamine and walking induced gamma oscillations in the medial prefrontal cortex and mediodorsal thalamus. PLoS One. 2017 Nov 2;12(11):e0186732. doi: 10.1371/journal.pone.0186732. PMID: 29095852; PMCID: PMC5667758. 6: Nakazawa S, Nakamichi K, Imai H, Ichihara J. Effect of dopamine D4 receptor agonists on sleep architecture in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Dec 3;63:6-13. doi: 10.1016/j.pnpbp.2015.05.006. Epub 2015 May 16. PMID: 25985889. 7: Tomlinson A, Grayson B, Marsh S, Hayward A, Marshall KM, Neill JC. Putative therapeutic targets for symptom subtypes of adult ADHD: D4 receptor agonism and COMT inhibition improve attention and response inhibition in a novel translational animal model. Eur Neuropsychopharmacol. 2015 Apr;25(4):454-67. doi: 10.1016/j.euroneuro.2014.11.016. Epub 2014 Dec 18. PMID: 25799918. 8: Good CH, Wang H, Chen YH, Mejias-Aponte CA, Hoffman AF, Lupica CR. Dopamine D4 receptor excitation of lateral habenula neurons via multiple cellular mechanisms. J Neurosci. 2013 Oct 23;33(43):16853-64. doi: 10.1523/JNEUROSCI.1844-13.2013. PMID: 24155292; PMCID: PMC3807019. 9: Kocsis B, Lee P, Deth R. Enhancement of gamma activity after selective activation of dopamine D4 receptors in freely moving rats and in a neurodevelopmental model of schizophrenia. Brain Struct Funct. 2014 Nov;219(6):2173-80. doi: 10.1007/s00429-013-0607-6. Epub 2013 Jul 10. PMID: 23839116; PMCID: PMC3859720. 10: Woolley ML, Waters KA, Reavill C, Bull S, Lacroix LP, Martyn AJ, Hutcheson DM, Valerio E, Bate S, Jones DN, Dawson LA. Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat. Behav Pharmacol. 2008 Dec;19(8):765-76. doi: 10.1097/FBP.0b013e32831c3b06. PMID: 19020411. 11: Browman KE, Curzon P, Pan JB, Molesky AL, Komater VA, Decker MW, Brioni JD, Moreland RB, Fox GB. A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats. Pharmacol Biochem Behav. 2005 Sep;82(1):148-55. doi: 10.1016/j.pbb.2005.08.002. Epub 2005 Sep 8. PMID: 16154186. 12: Moreland RB, Patel M, Hsieh GC, Wetter JM, Marsh K, Brioni JD. A-412997 is a selective dopamine D4 receptor agonist in rats. Pharmacol Biochem Behav. 2005 Sep;82(1):140-7. doi: 10.1016/j.pbb.2005.08.001. Epub 2005 Sep 8. PMID: 16153699.