MedKoo Cat#: 407176 | Name: UPF-1069
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

UPF-1069 is a selective and potent PARP2 inhibitor. UPF-1069 induces apoptosis. UPF-1069 shows neuroprotective and anti-ischemic effects in vivo.

Chemical Structure

UPF-1069
UPF-1069
CAS#1048371-03-4

Theoretical Analysis

MedKoo Cat#: 407176

Name: UPF-1069

CAS#: 1048371-03-4

Chemical Formula: C17H13NO3

Exact Mass: 279.0895

Molecular Weight: 279.29

Elemental Analysis: C, 73.11; H, 4.69; N, 5.02; O, 17.19

Price and Availability

Size Price Availability Quantity
50mg USD 250.00 2 Weeks
200mg USD 750.00 2 Weeks
1g USD 2,950.00 2 Weeks
2g USD 5,250.00 2 Weeks
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Related CAS #
No Data
Synonym
UPF-1069, UPF1069, UPF 1069
IUPAC/Chemical Name
5-(2-oxo-2-phenylethoxy)isoquinolin-1(2H)-one
InChi Key
JJWMRRNGWSITSQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H13NO3/c19-15(12-5-2-1-3-6-12)11-21-16-8-4-7-14-13(16)9-10-18-17(14)20/h1-10H,11H2,(H,18,20)
SMILES Code
O=C1NC=CC2=C1C=CC=C2OCC(C3=CC=CC=C3)=O
Appearance
White to off-white solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 279.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gerace E, Scartabelli T, Formentini L, Landucci E, Moroni F, Chiarugi A, Pellegrini-Giampietro DE. Mild activation of poly(ADP-ribose) polymerase (PARP) is neuroprotective in rat hippocampal slice models of ischemic tolerance. Eur J Neurosci. 2012 Jul;36(1):1993-2005. doi: 10.1111/j.1460-9568.2012.08116.x. Epub 2012 May 28. PubMed PMID: 22639866. 2: Moroni F, Formentini L, Gerace E, Camaioni E, Pellegrini-Giampietro DE, Chiarugi A, Pellicciari R. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. Br J Pharmacol. 2009 Jul;157(5):854-62. doi: 10.1111/j.1476-5381.2009.00232.x. Epub 2009 May 5. PubMed PMID: 19422384; PubMed Central PMCID: PMC2721269.