QNZ46 is an NMDA receptor antagonist. QNZ46 inhibits NMDA receptor function in a noncompetitive and voltage-independent manner by an unconventional mechanism that requires binding of glutamate to the GluN2 subunit, but not glycine binding to the GluN1 subunit. QNZ46 could provide an opportunity for the development of pharmacological tools and therapeutic agents that target NMDA receptors at a new site and modulate function by a novel mechanism. NMDA receptors are ionotropic glutamate receptors that mediate excitatory synaptic transmission and have been implicated in several neurological diseases.
MedKoo Cat#: 522398
Name: QNZ46
CAS#: 1237744-13-6
Chemical Formula: C24H17N3O6
Exact Mass: 443.1117
Molecular Weight: 443.42
Elemental Analysis: C, 65.01; H, 3.86; N, 9.48; O, 21.65
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.5 | 10.07 |
The following data is based on the product molecular weight 443.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
