NZ-28 | NSC134754 | CAS#75041-32-6 | HSF1 inhibitor

MedKoo Cat#: 407131 | Name: NZ-28

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NZ28, also known as NSC134754, is potent HSF1 inhibitor, which induced inhibition of HSF1, SP1 and NF-κB triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells. Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis.

Chemical Structure

NZ-28

CAS#75041-32-6

Theoretical Analysis

MedKoo Cat#: 407131

Name: NZ-28

CAS#: 75041-32-6

Chemical Formula: C27H34N2O2

Exact Mass: 418.2620

Molecular Weight: 418.58

Elemental Analysis: C, 77.48; H, 8.19; N, 6.69; O, 7.64

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

NZ-28; NZ28; NZ 28; NSC 134754; NSC 134754; NSC134754.

IUPAC/Chemical Name

(S)-3-ethyl-9,10-dimethoxy-2-(((R)-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-1,6,7,11b-tetrahydro-4H-pyrido[2,1-a]isoquinoline

InChi Key

HDIJLRXRAJUXQB-RPBOFIJWSA-N

InChi Code

InChI=1S/C27H34N2O2/c1-4-18-17-29-12-10-20-15-26(30-2)27(31-3)16-23(20)25(29)14-21(18)13-24-22-8-6-5-7-19(22)9-11-28-24/h5-8,15-16,24-25,28H,4,9-14,17H2,1-3H3/t24-,25+/m1/s1

SMILES Code

COC1=C(OC)C=C(CCN2CC(CC)=C(C[C@H]3NCCC4=C3C=CC=C4)C[C@]25[H])C5=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 418.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Schilling D, Kühnel A, Tetzlaff F, Konrad S, Multhoff G. NZ28-induced inhibition of HSF1, SP1 and NF-κB triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells. Cancer Immunol Immunother. 2015 May;64(5):599-608. doi: 10.1007/s00262-015-1665-9. Epub 2015 Feb 18. PubMed PMID: 25854583; PubMed Central PMCID: PMC4412431. 2: Schilling D, Kühnel A, Konrad S, Tetzlaff F, Bayer C, Yaglom J, Multhoff G. Sensitizing tumor cells to radiation by targeting the heat shock response. Cancer Lett. 2015 May 1;360(2):294-301. doi: 10.1016/j.canlet.2015.02.033. Epub 2015 Feb 23. PubMed PMID: 25721082. 3: Kudriavtsev VA, Makarova IuM, Kabakav AE. [Thermosensitization of tumor cells with inhibitors of chaperone activity and expression]. Biomed Khim. 2012 Nov-Dec;58(6):662-72. Russian. PubMed PMID: 23350198. 4: Meng L, Gabai VL, Sherman MY. Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis. Oncogene. 2010 Sep 16;29(37):5204-13. doi: 10.1038/onc.2010.277. Epub 2010 Jul 12. PubMed PMID: 20622894; PubMed Central PMCID: PMC2940982. 5: Zaarur N, Gabai VL, Porco JA Jr, Calderwood S, Sherman MY. Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors. Cancer Res. 2006 Feb 1;66(3):1783-91. PubMed PMID: 16452239. 6: Seppo A, Moreland M, Schweingruber H, Tiemeyer M. Zwitterionic and acidic glycosphingolipids of the Drosophila melanogaster embryo. Eur J Biochem. 2000 Jun;267(12):3549-58. PubMed PMID: 10848971.