Narazaciclib, also known as ON123300, is a potent multikinase inhibitor and may be potential useful for brain tumor chemotherapy. ON123300 strongly inhibits Ark5 and CDK4, as well as growth factor receptor tyrosine kinases such as β-type platelet-derived growth factor receptor (PDGFRβ). ON123300 inhibits U87 glioma cell proliferation with an IC(50) 3.4 ± 0.1 μmol/L. ON123300 exhibits potent activity against mantle cell lymphomas (MCLs) both in vitro and in vivo. ON123300 might be an effective agent in MCL, including ibrutinib-resistant forms of the disease.
MedKoo Cat#: 206460
Name: Narazaciclib
CAS#: 1357470-29-1
Chemical Formula: C24H27N7O
Exact Mass: 429.2277
Molecular Weight: 429.53
Elemental Analysis: C, 67.11; H, 6.34; N, 22.83; O, 3.72
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 16.0 | 37.25 | |
| DMF:PBS (pH 7.2) (1:2) | 0.3 | 0.70 | |
| DMSO | 18.6 | 43.20 | |
| Ethanol | 0.3 | 0.58 |
The following data is based on the product molecular weight 429.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
