Chrysin, a natural flavonoid primarily found in honey, propolis, and passion flowers, exhibits a wide range of bioactivities, including antioxidant, anti-inflammatory, anticancer, and anxiolytic effects. In vitro studies have demonstrated that chrysin inhibits cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression in LPS-stimulated macrophages, leading to reduced production of pro-inflammatory mediators (e.g., TNF-α, IL-6). In cancer models, chrysin has shown cytotoxic effects against various cancer cell lines, including MCF-7 (breast cancer, IC₅₀ ≈ 25 µM), HeLa (cervical cancer), and PC-3 (prostate cancer), by inducing apoptosis via modulation of the PI3K/Akt and MAPK pathways. Moreover, chrysin exhibits aromatase inhibitory activity (IC₅₀ ≈ 4.6 µM), making it of interest in hormone-sensitive cancers. However, its clinical potential is limited by poor oral bioavailability due to rapid metabolism (glucuronidation and sulfation), though formulation strategies are being explored to overcome this.
MedKoo Cat#: 600123
Name: Chrysin
CAS#: 480-40-0
Chemical Formula: C15H10O4
Exact Mass: 254.0579
Molecular Weight: 254.24
Elemental Analysis: C, 70.86; H, 3.96; O, 25.17
The following data is based on the product molecular weight 254.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
