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MedKoo Cat#: 145425 | Name: Wrightiadione

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Wrightiadione displays inhibitory activity toward TrkA and PLK3. Wrightiadione serves as a starting point for Trk inhibitor development campaigns. Wrightiadione contains a unique tetracyclic isoflavone moiety and has been shown to exhibit a broad range of biological activities.

Chemical Structure

Wrightiadione
Wrightiadione
CAS#148180-61-4

Theoretical Analysis

MedKoo Cat#: 145425

Name: Wrightiadione

CAS#: 148180-61-4

Chemical Formula: C16H8O3

Exact Mass: 248.0473

Molecular Weight: 248.24

Elemental Analysis: C, 77.42; H, 3.25; O, 19.34

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Wrightiadione;
IUPAC/Chemical Name
indeno[2,1-b]chromene-6,11-dione
InChi Key
CXXCRLLJRGEAJV-UHFFFAOYSA-N
InChi Code
1S/C16H8O3/c17-14-11-7-3-4-8-12(11)19-16-13(14)9-5-1-2-6-10(9)15(16)18/h1-8H
SMILES Code
O=C1C2=CC=CC=C2C3=C1OC4=C(C=CC=C4)C3=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 248.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Jeong Y, Lim SM, Hong S. Discovery of wrightiadione as a novel template for the TrkA kinase inhibitors. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5186-9. doi: 10.1016/j.bmcl.2015.09.070. Epub 2015 Sep 30. PMID: 26442778. 2: Garcellano RC, Moinuddin SGA, Young RP, Zhou M, Bowden ME, Renslow RS, Yesiltepe Y, Thomas DG, Colby SM, Chouinard CD, Nagy G, Attah IK, Ibrahim YM, Ma R, Franzblau SG, Lewis NG, Aguinaldo AM, Cort JR. Isolation of Tryptanthrin and Reassessment of Evidence for Its Isobaric Isostere Wrightiadione in Plants of the Wrightia Genus. J Nat Prod. 2019 Mar 22;82(3):440-448. doi: 10.1021/acs.jnatprod.8b00567. Epub 2018 Oct 8. PMID: 30295480. 3: De Los Reyes MM, Oyong GG, S Ng VA, Shen CC, Ragasa CY. Cytotoxic Compounds from Wrightia pubescens (R.Br.). Pharmacognosy Res. 2018 Jan- Mar;10(1):9-15. doi: 10.4103/pr.pr_45_17. PMID: 29568181; PMCID: PMC5855380. 4: Jeong Y, Moon Y, Hong S. Tandem Dehydrogenation/Oxidation/Oxidative Cyclization Approach to Wrightiadione and Its Derivatives. Org Lett. 2015 Jul 2;17(13):3252-5. doi: 10.1021/acs.orglett.5b01618. Epub 2015 Jun 19. PMID: 26090926. 5: Jannat T, Hossain MJ, El-Shehawi AM, Kuddus MR, Rashid MA, Albogami S, Jafri I, El-Shazly M, Haque MR. Chemical and Pharmacological Profiling of Wrightia coccinea (Roxb. Ex Hornem.) Sims Focusing Antioxidant, Cytotoxic, Antidiarrheal, Hypoglycemic, and Analgesic Properties. Molecules. 2022 Jun 22;27(13):4024. doi: 10.3390/molecules27134024. PMID: 35807270; PMCID: PMC9268577.