MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 510289 | Name: PEAQX sodium
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PEAQX, also known as NVP-AAM077; is a competitive antagonist at the NMDA receptor. Although originally described as 100-fold selective for GluN1/GluN2A receptors vs. GluN1/GluN2B receptors, more detailed studies of the Ki of PEAQX revealed it only shows a 5 fold difference in affinity for GluN1/GluN2A vs. GluN1/GluN2B receptors. It is also a potent anticonvulsant in animal tests.

Chemical Structure

PEAQX sodium
PEAQX sodium
CAS#2102348-87-6 (sodium)

Theoretical Analysis

MedKoo Cat#: 510289

Name: PEAQX sodium

CAS#: 2102348-87-6 (sodium)

Chemical Formula: C17H15BrN3Na4O6P

Exact Mass: 0.0000

Molecular Weight: 560.16

Elemental Analysis: C, 36.45; H, 2.70; Br, 14.26; N, 7.50; Na, 16.42; O, 17.14; P, 5.53

Price and Availability

Size Price Availability Quantity
5mg USD 1,950.00 2 Weeks
10mg USD 3,650.00 2 Weeks
50mg USD 6,950.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
459836-30-7 (free acid) 2102348-87-6 (sodium)
Synonym
NVP-AAM077; NVP-AAM 077; NVP-AAM-077; AAM-077; AAM077; AAM 077; PEAQX; PEAQX sodium; Peaqx Tetrasodium Salt
IUPAC/Chemical Name
sodium ((((S)-1-(4-bromophenyl)ethyl)amino)(2,3-dioxidoquinoxalin-5-yl)methyl)phosphonate hydrate .
InChi Key
SMGAGBKXHAHCGQ-VSYRWHDMSA-J
InChi Code
InChI=1S/C17H17BrN3O5P.4Na.H2O/c1-9(10-5-7-11(18)8-6-10)19-17(27(24,25)26)12-3-2-4-13-14(12)21-16(23)15(22)20-13;;;;;/h2-9,17,19H,1H3,(H,20,22)(H,21,23)(H2,24,25,26);;;;;1H2/q;4*+1;/p-4/t9-,17?;;;;;/m0...../s1
SMILES Code
[O-]C1=NC2=C(C(P([O-])([O-])=O)N[C@H](C3=CC=C(Br)C=C3)C)C=CC=C2N=C1[O-].[H]O[H].[Na+].[Na+].[Na+].[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
         
Product Data
Product Data
Instruction
View handling instruction
Biological target:
EAQX, also known as NVP-AAM077; is a competitive antagonist at the NMDA receptor.
In vitro activity:
Rhythmic bursts of spontaneous IPSCs (0.5 Hz average burst frequency) recorded from rat BLA principal cells were blocked or significantly suppressed by D-AP5, and could be driven by NMDAR activation alone. BLA interneurons generated spontaneous bursts of suprathreshold EPSCs at a similar frequency, which were also blocked or reduced by D-AP5. PEAQX (GluN2A-NMDAR antagonist; 0.4 μM) or Ro-25-6981 (GluN2B-NMDAR antagonist; 5 μM) suppressed the IPSC and EPSC bursts; suppression by PEAQX was significantly greater than that by Ro-25-6981. Reference: Neuroscience. 2018 Mar 1;373:145-158. https://pubmed.ncbi.nlm.nih.gov/29339324/
In vivo activity:
This study treated rats with an NR2A-preferring NMDA receptor antagonist (PEAQX, 10 mg/kg), an NR2B-selective NMDA receptor antagonist (ifenprodil, 7.5 mg/kg), or a nonselective blocker of the NMDA receptor (MK-801, 0.4 mg/kg) during the neonatal period. Rats neonatally treated with MK-801 or PEAQX showed spatial working memory deficits in the Y-maze test. PEAQX-treated rats also showed greater reactivity to acoustic stimuli and hypersensitivity to acute MK-801 challenge. Reference: Neurosci Res. 2022 Mar;176:57-65. https://pubmed.ncbi.nlm.nih.gov/34656645/

Preparing Stock Solutions

The following data is based on the product molecular weight 560.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Aroniadou-Anderjaska V, Pidoplichko VI, Figueiredo TH, Braga MFM. Oscillatory Synchronous Inhibition in the Basolateral Amygdala and its Primary Dependence on NR2A-containing NMDA Receptors. Neuroscience. 2018 Mar 1;373:145-158. doi: 10.1016/j.neuroscience.2018.01.021. Epub 2018 Jan 13. PMID: 29339324. 2. Wang WY, Jia LJ, Luo Y, Zhang HH, Cai F, Mao H, Xu WC, Fang JB, Peng ZY, Ma ZW, Chen YH, Zhang J, Wei Z, Yu BW, Hu SF. Location- and Subunit-Specific NMDA Receptors Determine the Developmental Sevoflurane Neurotoxicity Through ERK1/2 Signaling. Mol Neurobiol. 2016 Jan;53(1):216-230. doi: 10.1007/s12035-014-9005-1. Epub 2014 Nov 25. PMID: 25421211. 3. Furuie H, Yamada M. Neonatal blockade of NR2A-containing but not NR2B-containing NMDA receptor induces spatial working memory deficits in adult rats. Neurosci Res. 2022 Mar;176:57-65. doi: 10.1016/j.neures.2021.10.005. Epub 2021 Oct 14. PMID: 34656645. 4. Li Y, Lu YX, Chi HL, Xiao T, Chen YM, Fu LY, Zibrila AI, Qi J, Li HB, Su Q, Gao HL, Zhang Y, Shi XL, Yu XJ, Kang YM. Chronic Blockade of NMDAR Subunit 2A in the Hypothalamic Paraventricular Nucleus Alleviates Hypertension Through Suppression of MEK/ERK/CREB Pathway. Am J Hypertens. 2021 Aug 9;34(8):840-850. doi: 10.1093/ajh/hpab047. PMID: 33856436.
In vitro protocol:
1. Aroniadou-Anderjaska V, Pidoplichko VI, Figueiredo TH, Braga MFM. Oscillatory Synchronous Inhibition in the Basolateral Amygdala and its Primary Dependence on NR2A-containing NMDA Receptors. Neuroscience. 2018 Mar 1;373:145-158. doi: 10.1016/j.neuroscience.2018.01.021. Epub 2018 Jan 13. PMID: 29339324. 2. Wang WY, Jia LJ, Luo Y, Zhang HH, Cai F, Mao H, Xu WC, Fang JB, Peng ZY, Ma ZW, Chen YH, Zhang J, Wei Z, Yu BW, Hu SF. Location- and Subunit-Specific NMDA Receptors Determine the Developmental Sevoflurane Neurotoxicity Through ERK1/2 Signaling. Mol Neurobiol. 2016 Jan;53(1):216-230. doi: 10.1007/s12035-014-9005-1. Epub 2014 Nov 25. PMID: 25421211.
In vivo protocol:
1. Furuie H, Yamada M. Neonatal blockade of NR2A-containing but not NR2B-containing NMDA receptor induces spatial working memory deficits in adult rats. Neurosci Res. 2022 Mar;176:57-65. doi: 10.1016/j.neures.2021.10.005. Epub 2021 Oct 14. PMID: 34656645. 2. Li Y, Lu YX, Chi HL, Xiao T, Chen YM, Fu LY, Zibrila AI, Qi J, Li HB, Su Q, Gao HL, Zhang Y, Shi XL, Yu XJ, Kang YM. Chronic Blockade of NMDAR Subunit 2A in the Hypothalamic Paraventricular Nucleus Alleviates Hypertension Through Suppression of MEK/ERK/CREB Pathway. Am J Hypertens. 2021 Aug 9;34(8):840-850. doi: 10.1093/ajh/hpab047. PMID: 33856436.
1: Park EH, Kao HY, Jourdi H, van Dijk MT, Carrillo-Segura S, Tunnell KW, Gutierrez J, Wallace EJ, Troy-Regier M, Radwan B, Lesburguères E, Alarcon JM, Fenton AA. Phencyclidine Disrupts Neural Coordination and Cognitive Control by Dysregulating Translation. Biol Psychiatry Glob Open Sci. 2023 May 31;4(1):252-263. doi: 10.1016/j.bpsgos.2023.04.009. PMID: 38298788; PMCID: PMC10829677. 2: Huang H, Jiang H, Sun H. GluN2A Mediates PS-Induced Depressive-Like Behavior by Activating CaMKII and Inhibiting Myelinization. Front Biosci (Landmark Ed). 2023 Dec 26;28(12):347. doi: 10.31083/j.fbl2812347. PMID: 38179739. 3: Rojvirat CP, Berlin JR, Nguyen TD. Evaluating spatial and network properties of NMDA-dependent neuronal connectivity in mixed cortical cultures. Brain Res. 2022 Jul 15;1787:147919. doi: 10.1016/j.brainres.2022.147919. Epub 2022 Apr 15. PMID: 35436447. 4: Liu Y, Fu X, Liu Y, Zhang T, Cui P, Wang S, Liu L, Hou Z, Wang H, Zhao Y, Zhang Z, Zhang H, Wu C, Yang J. Neuroprotective effect of pseudoginsenoside-F11 on permanent cerebral ischemia in rats by regulating calpain activity and NR2A submit-mediated AKT-CREB signaling pathways. Phytomedicine. 2022 Feb;96:153847. doi: 10.1016/j.phymed.2021.153847. Epub 2021 Nov 3. PMID: 34836744. 5: Wu GM, Du CP, Xu Y. Oligomeric Aβ25-35 induces the tyrosine phosphorylation of PSD-95 by SrcPTKs in rat hippocampal CA1 subfield. Int J Neurosci. 2023 Dec;133(8):888-895. doi: 10.1080/00207454.2021.2010732. Epub 2021 Dec 9. PMID: 34818135. 6: Yao H, Liu W, Liao H, Sheng T, Chen P, Zhou H, Pan Y, Xie J, Zhang Q, Zou Z, Chen Z. Geniposide attenuates postischemic long-term potentiation via GluN2A. Pak J Pharm Sci. 2021 May;34(3):909-914. PMID: 34602413. 7: Wang C, Yu Q, Li D, Sun N, Huang Y, Zhang YX, Zhou WX. Reduced D-Serine Release May Contribute to Impairment of Long-Term Potentiation by Corticosterone in the Perforant Path-Dentate Gyrus. Neurochem Res. 2021 Sep;46(9):2359-2375. doi: 10.1007/s11064-021-03380-4. Epub 2021 Jun 19. PMID: 34146194. 8: Xue M, Zhou SB, Liu RH, Chen QY, Zhuo M, Li XH. NMDA Receptor-Dependent Synaptic Depression in Potentiated Synapses of the Anterior Cingulate Cortex of adult Mice. Mol Pain. 2021 Jan-Dec;17:17448069211018045. doi: 10.1177/17448069211018045. PMID: 34024172; PMCID: PMC8141994. 9: Hu W, He J, Wang Y, Xu L, Zhao Y, Hu X, Shen H. Protective effect of Achyranthes bidentata polypeptides on NMDA-mediated injury is developmentally regulated via modulating NR2A and NR2B differentially. Ann Transl Med. 2021 Feb;9(3):248. doi: 10.21037/atm-20-581. PMID: 33708875; PMCID: PMC7940890. 10: Gonda S, Giesen J, Sieberath A, West F, Buchholz R, Klatt O, Ziebarth T, Räk A, Kleinhubbert S, Riedel C, Hollmann M, Hamad MIK, Reiner A, Wahle P. GluN2B but Not GluN2A for Basal Dendritic Growth of Cortical Pyramidal Neurons. Front Neuroanat. 2020 Nov 13;14:571351. doi: 10.3389/fnana.2020.571351. PMID: 33281565; PMCID: PMC7691608. 11: Liang Y, Ma Y, Wang J, Nie L, Hou X, Wu W, Zhang X, Tian Y. Leptin Contributes to Neuropathic Pain via Extrasynaptic NMDAR-nNOS Activation. Mol Neurobiol. 2021 Mar;58(3):1185-1195. doi: 10.1007/s12035-020-02180-1. Epub 2020 Oct 25. PMID: 33099751; PMCID: PMC7878206. 12: Bu F, Yuan M, Ma D, Zhu Y, Wang M. Inhibition of NR2A reduces calcitonin gene-related peptide gene expression induced by cortical spreading depression in rat amygdala. Neuropeptides. 2020 Dec;84:102097. doi: 10.1016/j.npep.2020.102097. Epub 2020 Oct 8. PMID: 33059243. 13: Zhang XY, Zhang GJ, Li BX, Bing YH, Cui BR, Cui LN, Chu CP, Qiu DL. NMDARs contribute to the facial stimuli-evoked mossy fiber-granule cell synaptic transmission in vivo in mice. Neurosci Lett. 2020 Sep 25;736:135285. doi: 10.1016/j.neulet.2020.135285. Epub 2020 Aug 2. PMID: 32755629. 14: Liu XY, Yao B, Hao JR, Jin L, Gao Y, Yang X, Liu L, Sun XY, Sun N, Gao C. IQGAP1/ERK regulates fear memory formation via histone posttranslational modifications induced by HDAC2. Neurobiol Learn Mem. 2020 May;171:107210. doi: 10.1016/j.nlm.2020.107210. Epub 2020 Mar 5. PMID: 32145408. 15: Bu F, Nie L, Quinn JP, Wang M. Sarcoma Family Kinase-Dependent Pannexin-1 Activation after Cortical Spreading Depression is Mediated by NR2A-Containing Receptors. Int J Mol Sci. 2020 Feb 13;21(4):1269. doi: 10.3390/ijms21041269. PMID: 32070042; PMCID: PMC7072958. 16: Li H, Luo XB, Xu Y, Hou XY. A Brief Ischemic Postconditioning Protects Against Amyloid-β Peptide Neurotoxicity by Downregulating MLK3-MKK3/6-P38MAPK Signal in Rat Hippocampus. J Alzheimers Dis. 2019;71(2):671-684. doi: 10.3233/JAD-190207. PMID: 31424393. 17: Shi X, von Weltin E, Barr JL, Unterwald EM. Activation of GSK3β induced by recall of cocaine reward memories is dependent on GluN2A/B NMDA receptor signaling. J Neurochem. 2019 Oct;151(1):91-102. doi: 10.1111/jnc.14842. Epub 2019 Aug 25. PMID: 31361029; PMCID: PMC6788955. 18: Rajagopal S, Fitzgerald AA, Deep SN, Paul S, Poddar R. Role of GluN2A NMDA receptor in homocysteine-induced prostaglandin E2 release from neurons. J Neurochem. 2019 Jul;150(1):44-55. doi: 10.1111/jnc.14775. Epub 2019 Jun 20. PMID: 31125437; PMCID: PMC7263633. 19: Wei X, Nishi T, Kondou S, Kimura H, Mody I. Preferential enhancement of GluN2B-containing native NMDA receptors by the endogenous modulator 24S-hydroxycholesterol in hippocampal neurons. Neuropharmacology. 2019 Apr;148:11-20. doi: 10.1016/j.neuropharm.2018.12.028. Epub 2018 Dec 27. PMID: 30594698; PMCID: PMC6424632. 20: Yu X, Jia L, Yin K, Lv J, Yu W, Du H. Src is Implicated in Hepatic Ischemia Reperfusion-Induced Hippocampus Injury and Long-Term Cognitive Impairment in Young Mice via NMDA Receptor Subunit 2A Activation. Neuroscience. 2018 Nov 1;391:1-12. doi: 10.1016/j.neuroscience.2018.08.034. Epub 2018 Sep 11. PMID: 30213765.