Y11 | CAS# 1086639-59-9 | FAK inhibitor

MedKoo Cat#: 406462 | Name: Y11

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Y11 is a small molecule inhibitor targeting Y397 site of FAK. Y11 significantly and specifically decreased FAK autophosphorylation, directly bound to the N-terminal domain of FAK. In addition, Y11 decreased Y397-FAK autophosphorylation, inhibited viability and clonogenicity of colon SW620 and breast BT474 cancer cells and increased detachment and apoptosis in vitro. Moreover, Y11 significantly decreased tumor growth in the colon cancer cell mouse xenograft model. Finally, tumors from the Y11-treated mice demonstrated decreased Y397-FAK autophosphorylation and activation of poly (ADP ribose) polymerase and caspase-3.

Chemical Structure

Y11

CAS#1086639-59-9

Theoretical Analysis

MedKoo Cat#: 406462

Name: Y11

CAS#: 1086639-59-9

Chemical Formula: C8H17BrN4O

Exact Mass: 264.0586

Molecular Weight: 265.15

Elemental Analysis: C, 36.24; H, 6.46; Br, 30.14; N, 21.13; O, 6.03

Price and Availability

Size	Price	Availability
10mg	USD 400.00	2 Weeks
25mg	USD 750.00	2 Weeks
50mg	USD 1,250.00	2 Weeks

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Related CAS #

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Synonym

Y11; Y-11; Y 11

IUPAC/Chemical Name

(3r,5r,7r)-1-(2-hydroxyethyl)-1,3,5,7-tetraazaadamantan-1-ium bromide

InChi Key

HBPXFHNNLMCUPA-UHFFFAOYSA-M

InChi Code

InChI=1S/C8H17N4O.BrH/c13-2-1-12-6-9-3-10(7-12)5-11(4-9)8-12;/h13H,1-8H2;1H/q+1;/p-1

SMILES Code

OCC[N+]12C[N@]3C[N@](C2)C[N@](C3)C1.[Br-]

Appearance

white solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 265.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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