AR-R17779 HCl | CAS#178419-42-6 | 178419-47-1 | alpha7 nicotinic agonist

MedKoo Cat#: 530349 | Name: AR-R17779 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AR-R17779 is a selective alpha7 nicotinic agonist (Ki values are 190 and 16000 nM for rat α7 and α4β2 receptors respectively). AR-R17779 improves learning and memory in rats. Treatment with AR-R17779 significantly reduced atherosclerotic plaque area and improved survival of mice. Treatment with AR-R17779 also suppressed abdominal aortic aneurysm formation. Quantitative RT-PCR of the aorta revealed that mRNA expression levels of interleukin-1β, interleukin-6 and NOX2 were significantly decreased in AR-R17779-treated mice compared with Ang II+HFD mice. AR-R17779 treatment also reduced blood pressure and serum lipid levels.

Chemical Structure

AR-R17779 HCl

CAS#178419-42-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 530349

Name: AR-R17779 HCl

CAS#: 178419-42-6 (HCl)

Chemical Formula: C9H15ClN2O2

Exact Mass: 0.0000

Molecular Weight: 218.68

Elemental Analysis: C, 49.43; H, 6.91; Cl, 16.21; N, 12.81; O, 14.63

Price and Availability

Size	Price	Availability
5mg	USD 305.00	2 Weeks
25mg	USD 850.00	2 Weeks
200mg	USD 2,650.00	2 Weeks
500mg	USD 3,650.00	2 Weeks
1g	USD 4,750.00	2 Weeks

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Related CAS #

178419-42-6 (HCl) 178419-47-1 (free base)

Synonym

AR-R17779 hydrochloride; AR-R17779; AR-R-17779; AR-R 17779.

IUPAC/Chemical Name

(3S)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidine]-2'-one hydrochloride

InChi Key

XGLBLUBBDSJBIU-FVGYRXGTSA-N

InChi Code

InChI=1S/C9H14N2O2.ClH/c12-8-10-5-9(13-8)6-11-3-1-7(9)2-4-11;/h7H,1-6H2,(H,10,12);1H/t9-;/m0./s1

SMILES Code

O=C(NC1)O[C@@]21CN3CCC2CC3.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Related CAS# CAS#178419-42-6 (AR-R17779 hydrochloride) CAS#178419-47-1 (AR-R17779 free base)

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 218.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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