Tenovin-1 | CAS#380315-80-0 | p53 activator

MedKoo Cat#: 406723 | Name: Tenovin-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tenovin-1 is a p53 activator that protects against MDM2-mediated p53 degradation. Tenovin-1 is also a selective SIRT1/2 inhibitor

Chemical Structure

Tenovin-1

CAS#380315-80-0

Theoretical Analysis

MedKoo Cat#: 406723

Name: Tenovin-1

CAS#: 380315-80-0

Chemical Formula: C20H23N3O2S

Exact Mass: 369.1511

Molecular Weight: 369.48

Elemental Analysis: C, 65.01; H, 6.27; N, 11.37; O, 8.66; S, 8.68

Price and Availability

Size	Price	Availability
50mg	USD 450.00	2 Weeks
100mg	USD 700.00	2 Weeks
200mg	USD 1,050.00	2 Weeks

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Related CAS #

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Synonym

Tenovin1

IUPAC/Chemical Name

N -[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide

InChi Key

WOWJIWFCOPZFGV-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H23N3O2S/c1-13(24)21-16-9-11-17(12-10-16)22-19(26)23-18(25)14-5-7-15(8-6-14)20(2,3)4/h5-12H,1-4H3,(H,21,24)(H2,22,23,25,26)

SMILES Code

O=C(NC(NC1=CC=C(NC(C)=O)C=C1)=S)C2=CC=C(C(C)(C)C)C=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>5 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 369.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sharma S, Gali S, Kundu A, Park JH, Kim JS, Kim HS. Tenovin-1, a Selective SIRT1/2 Inhibitor, Attenuates High-fat Diet-induced Hepatic Fibrosis via Inhibition of HSC Activation in ZDF Rats. Int J Biol Sci. 2024 Jun 11;20(9):3334-3352. doi: 10.7150/ijbs.97304. PMID: 38993557; PMCID: PMC11234213. 2: Liu X, Xu Z, Liang J, Yu L, Ren P, Zhou HB, Wu S, Lan K. Identification of a novel acylthiourea-based potent broad-spectrum inhibitor for enterovirus 3D polymerase in vitro and in vivo. Antiviral Res. 2023 May;213:105583. doi: 10.1016/j.antiviral.2023.105583. Epub 2023 Mar 23. PMID: 36965527. 3: Xiao F, Qin Y, Chen J, Li C, Qin Y, Wei Y, Xie Y. The propofol-induced mitochondrial damage in fetal rat hippocampal neurons via the AMPK/P53 signaling pathway. Ann Transl Med. 2022 Oct;10(20):1106. doi: 10.21037/atm-22-4374. PMID: 36388781; PMCID: PMC9652519. 4: Li S, Wu L, Ma M, Yang L, Qin C. MicroRNA-668-3p regulates oxidative stress and cell damage induced by Aβ1-42 by targeting the OXR1/p53-p21 axis. Ann Transl Med. 2022 Sep;10(17):928. doi: 10.21037/atm-22-3598. PMID: 36172098; PMCID: PMC9511202. 5: Kundu A, Gali S, Sharma S, Park JH, Kyung SY, Kacew S, Kim IS, Lee KY, Kim HS. Tenovin-1 Ameliorates Renal Fibrosis in High-Fat-Diet-Induced Diabetic Nephropathy via Antioxidant and Anti-Inflammatory Pathways. Antioxidants (Basel). 2022 Sep 14;11(9):1812. doi: 10.3390/antiox11091812. PMID: 36139886; PMCID: PMC9495519. 6: Wan Y, Wu W, Zhang J, Li L, Wan Y, Tang X, Chen X, Liu S, Yao X. Tenovin-1 inhibited dengue virus replication through SIRT2. Eur J Pharmacol. 2021 Sep 15;907:174264. doi: 10.1016/j.ejphar.2021.174264. Epub 2021 Jun 17. PMID: 34147476. 7: Gan N, Sun Q, Suo Z, Zhang S, Zhao L, Xiang H, Wang W, Li Z, Liao X, Li H. How hydrophilic group affects drug-protein binding modes: Differences in interaction between sirtuins inhibitors Tenovin-1/Tenovin-6 and human serum albumin. J Pharm Biomed Anal. 2021 Jul 15;201:114121. doi: 10.1016/j.jpba.2021.114121. Epub 2021 May 7. PMID: 34020341. 8: Chen E, Li E, Liu H, Zhou Y, Wen L, Wang J, Wang Y, Ye L, Liang T. miR-26b enhances the sensitivity of hepatocellular carcinoma to Doxorubicin via USP9X-dependent degradation of p53 and regulation of autophagy. Int J Biol Sci. 2021 Feb 8;17(3):781-795. doi: 10.7150/ijbs.52517. PMID: 33767588; PMCID: PMC7975695. 9: Hirota C, Takashina Y, Ikumi N, Ishizuka N, Hayashi H, Tabuchi Y, Yoshino Y, Matsunaga T, Ikari A. Inverse regulation of claudin-2 and -7 expression by p53 and hepatocyte nuclear factor 4α in colonic MCE301 cells. Tissue Barriers. 2021 Jan 2;9(1):1860409. doi: 10.1080/21688370.2020.1860409. Epub 2020 Dec 23. PMID: 33356822; PMCID: PMC7849757. 10: Ladds MJGW, Popova G, Pastor-Fernández A, Kannan S, van Leeuwen IMM, Håkansson M, Walse B, Tholander F, Bhatia R, Verma CS, Lane DP, Laín S. Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology. J Biol Chem. 2020 Dec 25;295(52):17935-17949. doi: 10.1074/jbc.RA119.012056. Epub 2020 Sep 8. PMID: 32900849; PMCID: PMC7939445. 11: Gao Y, Cui X, Wang M, Zhang Y, He Y, Li L, Li H, Zhang X, Cheng M. Oscillatory shear stress induces the transition of EPCs into mesenchymal cells through ROS/PKCζ/p53 pathway. Life Sci. 2020 Jul 15;253:117728. doi: 10.1016/j.lfs.2020.117728. Epub 2020 Apr 27. PMID: 32353430. 12: Wu S, Yao W, Chen C, Chen H, Huang F, Liu Y, Cai J, Yuan D, Hei Z. Connexin 32 deficiency protects the liver against ischemia/reperfusion injury. Eur J Pharmacol. 2020 Jun 5;876:173056. doi: 10.1016/j.ejphar.2020.173056. Epub 2020 Mar 5. PMID: 32147436. 13: Hackett BA, Dittmar M, Segrist E, Pittenger N, To J, Griesman T, Gordesky- Gold B, Schultz DC, Cherry S. Sirtuin Inhibitors Are Broadly Antiviral against Arboviruses. mBio. 2019 Jul 9;10(4):e01446-19. doi: 10.1128/mBio.01446-19. PMID: 31289184; PMCID: PMC6747726. 14: Chen YN, Ren CC, Yang L, Nai MM, Xu YM, Zhang F, Liu Y. MicroRNA let‑7d‑5p rescues ovarian cancer cell apoptosis and restores chemosensitivity by regulating the p53 signaling pathway via HMGA1. Int J Oncol. 2019 May;54(5):1771-1784. doi: 10.3892/ijo.2019.4731. Epub 2019 Feb 27. PMID: 30816441. 15: Bang M, Ryu O, Kim DG, Mabunga DF, Cho KS, Kim Y, Han SH, Kwon KJ, Shin CY. Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes. Biomol Ther (Seoul). 2019 May 1;27(3):283-289. doi: 10.4062/biomolther.2018.107. PMID: 30092626; PMCID: PMC6513186. 16: Marx C, Marx-Blümel L, Lindig N, Thierbach R, Hoelzer D, Becker S, Wittig S, Lehmann R, Slevogt H, Heinzel T, Wang ZQ, Beck JF, Sonnemann J. The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing's sarcoma cell line. Invest New Drugs. 2018 Jun;36(3):396-406. doi: 10.1007/s10637-017-0541-1. Epub 2017 Nov 18. PMID: 29150734. 17: Marx-Blümel L, Marx C, Kühne M, Sonnemann J. Assessment of HDACi-Induced Cytotoxicity. Methods Mol Biol. 2017;1510:23-45. doi: 10.1007/978-1-4939-6527-4_3. PMID: 27761811. 18: Yoon KB, Park KR, Kim SY, Han SY. Induction of Nuclear Enlargement and Senescence by Sirtuin Inhibitors in Glioblastoma Cells. Immune Netw. 2016 Jun;16(3):183-8. doi: 10.4110/in.2016.16.3.183. Epub 2016 Jun 17. PMID: 27340387; PMCID: PMC4917402. 19: Chen L, Ahmad N, Liu X. Combining p53 stabilizers with metformin induces synergistic apoptosis through regulation of energy metabolism in castration- resistant prostate cancer. Cell Cycle. 2016;15(6):840-9. doi: 10.1080/15384101.2016.1151582. PMID: 26900800; PMCID: PMC4845973. 20: Raza S, Ohm JE, Dhasarathy A, Schommer J, Roche C, Hammer KD, Ghribi O. The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells. Mol Cell Biochem. 2015 Dec;410(1-2):187-95. doi: 10.1007/s11010-015-2551-7. Epub 2015 Sep 8. PMID: 26350565; PMCID: PMC4821067.