MV-151 | MV151 | CAS#945611-88-1 | Protease inhibitor

MedKoo Cat#: 406546 | Name: MV151

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MV151 is a fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo. MV151 specifically targets all active subunits of the proteasome and immunoproteasome in living cells, allowing for rapid and sensitive in-gel detection. The inhibition profile of a panel of commonly used proteasome inhibitors could be readily determined by MV151 labeling. Administration of MV151 to mice allowed for in vivo labeling of proteasomes, which correlated with inhibition of proteasomal degradation in the affected tissues. This probe can be used for many applications ranging from clinical profiling of proteasome activity, to biochemical analysis of subunit specificity of inhibitors, and to cell biological analysis of the proteasome function and dynamics in living cells. MV-152 is an inactive form of MV-151.

Chemical Structure

MV151

CAS#945611-88-1 (MV-151)

Theoretical Analysis

MedKoo Cat#: 406546

Name: MV151

CAS#: 945611-88-1 (MV-151)

Chemical Formula: C59H91BF2N8O9S

Exact Mass: 1136.6691

Molecular Weight: 1137.27

Elemental Analysis: C, 62.31; H, 8.07; B, 0.95; F, 3.34; N, 9.85; O, 12.66; S, 2.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

945611-88-1 (MV-151) 945611-89-2 (MV-152)

Synonym

MV151; MV 151; MV-151; Bodipy TMRAhx(3)L(3)VS.

IUPAC/Chemical Name

6-(3-(5,5-difluoro-7-(4-methoxyphenyl)-1,3-dimethyl-5H-4l4,5l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-2-yl)propanamido)-N-((4S,7S,10S)-7,10-diisobutyl-2-methyl-4-((E)-2-(methylsulfonyl)vinyl)-6,9,12,19-tetraoxo-5,8,11,18-tetraazatetracosan-24-yl)hexanamide

InChi Key

JNIDQOOVQFMCNR-FWDZYPIVSA-N

InChi Code

InChI=1S/C59H91BF2N8O9S/c1-40(2)36-46(31-35-80(10,77)78)66-58(75)51(38-42(5)6)68-59(76)50(37-41(3)4)67-57(74)22-16-13-19-33-64-55(72)20-14-11-17-32-63-54(71)21-15-12-18-34-65-56(73)30-28-49-43(7)53-39-47-25-29-52(45-23-26-48(79-9)27-24-45)70(47)60(61,62)69(53)44(49)8/h23-27,29,31,35,39-42,46,50-51H,11-22,28,30,32-34,36-38H2,1-10H3,(H,63,71)(H,64,72)(H,65,73)(H,66,75)(H,67,74)(H,68,76)/b35-31+/t46-,50+,51+/m1/s1

SMILES Code

CC(C(CCC(NCCCCCC(NCCCCCC(NCCCCCC(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)/C=C/S(C)(=O)=O)=O)=O)=O)=O)=O)=O)=C1C)=[N+]2C1=CC3=CC=C(C4=CC=C(OC)C=C4)N3[B-](F)2F

Appearance

white solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,137.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Türker F, Bharadwaj RA, Kleinman JE, Weinberger DR, Hyde TM, White CJ, Williams DW, Margolis SS. Orthogonal approaches required to measure proteasome composition and activity in mammalian brain tissue. J Biol Chem. 2023 Jun;299(6):104811. doi: 10.1016/j.jbc.2023.104811. Epub 2023 May 11. PMID: 37172721; PMCID: PMC10276296. 2: Li C, Bundschuh J, Gao X, Li Y, Zhang X, Luo W, Pan Z. Occurrence and behavior of arsenic in groundwater-aquifer system of irrigated areas. Sci Total Environ. 2022 Sep 10;838(Pt 1):155991. doi: 10.1016/j.scitotenv.2022.155991. Epub 2022 May 16. PMID: 35588806. 3: Xia Q, El-Maarouf-Bouteau H, Bailly C, Meimoun P. Determination of Protein Carbonylation and Proteasome Activity in Seeds. Methods Mol Biol. 2016;1450:205-12. doi: 10.1007/978-1-4939-3759-2_16. PMID: 27424756. 4: Verdoes M, Florea BI, Menendez-Benito V, Maynard CJ, Witte MD, van der Linden WA, van den Nieuwendijk AM, Hofmann T, Berkers CR, van Leeuwen FW, Groothuis TA, Leeuwenburgh MA, Ovaa H, Neefjes JJ, Filippov DV, van der Marel GA, Dantuma NP, Overkleeft HS. A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo. Chem Biol. 2006 Nov;13(11):1217-26. doi: 10.1016/j.chembiol.2006.09.013. PMID: 17114003.