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MedKoo Cat#: 129091 | Name: CWHM-1023

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CWHM-1023 is a M. tuberculosis QcrB inhibitor with IC50 = 42 nM.

Chemical Structure

CWHM-1023
CWHM-1023
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 129091

Name: CWHM-1023

CAS#: N/A

Chemical Formula: C18H21N3S

Exact Mass: 311.1456

Molecular Weight: 311.45

Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: Elemental Analysis: C, 69.42; H, 6.80; N, 13.49; S, 10.29

Price and Availability

Related CAS #
No Data
Synonym
CWHM-1023; CWHM1023; CWHM 1023
IUPAC/Chemical Name
2-ethyl-6-methyl-N-(3-phenylpropyl)thieno[2,3-d]pyrimidin-4-amine
InChi Key
JMFHPUKSQVURSF-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H21N3S/c1-3-16-20-17(15-12-13(2)22-18(15)21-16)19-11-7-10-14-8-5-4-6-9-14/h4-6,8-9,12H,3,7,10-11H2,1-2H3,(H,19,20,21)
SMILES Code
CC(S1)=CC2=C1N=C(CC)N=C2NCCCC3=CC=CC=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 311.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Harrison GA, Mayer Bridwell AE, Singh M, Jayaraman K, Weiss LA, Kinsella RL, Aneke JS, Flentie K, Schene ME, Gaggioli M, Solomon SD, Wildman SA, Meyers MJ, Stallings CL. Identification of 4-Amino-Thieno[2,3-d]Pyrimidines as QcrB Inhibitors in Mycobacterium tuberculosis. mSphere. 2019 Sep 11;4(5):e00606-19. doi: 10.1128/mSphere.00606-19. PMID: 31511370; PMCID: PMC6739496.