CX-116 exhibits potent anti-inflammatory activity and effectively protects cells from cisplatin toxicity. CX116 exerts its effects by inhibiting the inflammatory response, reducing oxidative stress, protecting mitochondrial function, and counteracting apoptosis. In vivo studies showed that CX116 bears acceptable toxicity and appropriate pharmacokinetic properties, and significantly protects renal tissue from cisplatin-induced damage in a cis-AKI animal model. Inconclusion, CX116 is a highly promising active molecule and holds great potential for the development of therapeutic drugs for cis-AKI.
MedKoo Cat#: 128992
Name: CX116
CAS#: N/A
Chemical Formula: C23H40N6O3
Exact Mass: 448.3162
Molecular Weight: 448.61
Elemental Analysis: C, 61.58; H, 8.99; N, 18.73; O, 10.70
The following data is based on the product molecular weight 448.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
