ADX-88178 is a novel potent, selective, and brain-penetrant positive allosteric modulator of the mGlu4 receptor in rodent models of anxiety, obsessive compulsive disorder (OCD), fear, depression, and psychosis. ADX88178 dose-dependently reduced the number of buried marbles in the marble burying test and increased open-arm exploration in the elevated plus maze (EPM) test, indicative of anxiolytic-like efficacy.
MedKoo Cat#: 129079
Name: ADX-88178 TFA
CAS#: ADX-88178 TFA
Chemical Formula: C14H13F3N6O2S
Exact Mass: 0.0000
Molecular Weight: 386.35
Elemental Analysis: C, 43.52; H, 3.39; F, 14.75; N, 21.75; O, 8.28; S, 8.30
The following data is based on the product molecular weight 386.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. A potent and selective metabotropic glutamate receptor 4 positive allosteric modulator improves movement in rodent models of Parkinson’s disease. J. Pharmacol. Exp. Ther. 343(1), 167-177 (2012).
2. Metabotropic glutamate receptor 4 (mGlu4) positive allosteric modulators lack efficacy in rat and marmoset models of L-
