dPDL1-4 is a PD-L1 degrader. dPDL1-4 selectively degraded membrane PD-L1 in tumor cells over normal cells, leveraging the elevated expression of eHSP90 in cancer cells. Moreover, dPDL1-4 demonstrated robust in vivo degradation of membrane PD-L1 and significant tumor growth suppression in the B16F10 syngeneic mouse model.
MedKoo Cat#: 129056
Name: dPDL1-4
CAS#: N/A
Chemical Formula: C63H80BrN7O10
Exact Mass: 1173.5200
Molecular Weight: 1175.28
Elemental Analysis: C, 64.38; H, 6.86; Br, 6.80; N, 8.34; O, 13.61
The following data is based on the product molecular weight 1,175.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Zhang D, Li J, Liang Y, Li T, Ji M, Liu X, Li W, Chen P, Zhang J, Yang Z, Wang L, Chen H. Extracellular HSP90-Facilitated Degradation of Extracellular and Membrane Proteins by Bifunctional Small Molecules. J Med Chem. 2025 Jun 11. doi: 10.1021/acs.jmedchem.5c00379. Epub ahead of print. PMID: 40497783.
