ARM-165 | a PI3K PROTAC degrader

MedKoo Cat#: 129051 | Name: ARM-165

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ARM-165 is a PI3K PROTAC degrader.

Chemical Structure

ARM-165

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 129051

Name: ARM-165

CAS#: N/A

Chemical Formula: C44H51N7O8S

Exact Mass: 837.3500

Molecular Weight: 837.99

Elemental Analysis: C, 63.07; H, 6.13; N, 11.70; O, 15.27; S, 3.83

Price and Availability

Related CAS #

No Data

Synonym

ARM-165; ARM165; ARM 165

IUPAC/Chemical Name

N1-(5-(2-((S)-1-cyclopropylethyl)-7-methyl-1-oxoisoindolin-5-yl)-4-methylthiazol-2-yl)-N5-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-8-oxooctyl)glutaramide

InChi Key

HPQOLTMYIUOBAP-RNWYOQHESA-N

InChi Code

InChI=1S/C44H51N7O8S/c1-24-21-28(22-29-23-50(42(58)37(24)29)26(3)27-16-17-27)39-25(2)46-44(60-39)49-35(54)15-10-14-33(52)45-20-8-6-4-5-7-13-34(53)47-31-12-9-11-30-38(31)43(59)51(41(30)57)32-18-19-36(55)48-40(32)56/h9,11-12,21-22,26-27,32H,4-8,10,13-20,23H2,1-3H3,(H,45,52)(H,47,53)(H,46,49,54)(H,48,55,56)/t26-,32?/m0/s1

SMILES Code

CC1=C2C(N(CC2=CC(C3=C(N=C(S3)NC(CCCC(NCCCCCCCC(NC4=CC=CC5=C4C(N(C5=O)C6CCC(NC6=O)=O)=O)=O)=O)=O)C)=C1)[C@H](C7CC7)C)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Biological target:

In vitro activity:

In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 837.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

In vitro protocol:

In vivo protocol:

Kelly LM, Rutter JC, Lin KH, Ling F, Duchmann M, Latour E, Arang N, Pasquer H, Ho Nhat D, Charles J, Killarney ST, Ang HX, Namor F, Culeux C, Lombard B, Loew D, Swaney DL, Krogan NJ, Brunel L, Carretero É, Verdié P, Amblard M, Fodil S, Huynh T, Sebert M, Adès L, Raffoux E, Fenouille N, Itzykson R, Lobry C, Benajiba L, Forget A, Martin AR, Wood KC, Puissant A. Targeting a lineage-specific PI3Kɣ-Akt signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule. Nat Cancer. 2024 Jul;5(7):1082-1101. doi: 10.1038/s43018-024-00782-5. Epub 2024 May 30. PMID: 38816660; PMCID: PMC11778622.