Synonym
LDR102; LDR 102; LDR-102
IUPAC/Chemical Name
3-((1H-pyrazolo[3,4-b]pyridin-4-yl)ethynyl)-N-(3-(4-(methoxymethoxy)phenyl)-1-methyl-1H-indol-6-yl)-4-methylbenzamide
InChi Key
JOSUWBQNUKVUJH-UHFFFAOYSA-N
InChi Code
InChI=1S/C33H27N5O3/c1-21-4-5-25(16-24(21)7-6-23-14-15-34-32-29(23)18-35-37-32)33(39)36-26-10-13-28-30(19-38(2)31(28)17-26)22-8-11-27(12-9-22)41-20-40-3/h4-5,8-19H,20H2,1-3H3,(H,36,39)(H,34,35,37)
SMILES Code
CC(C=CC(C(NC1=CC(N(C)C=C2C3=CC=C(OCOC)C=C3)=C2C=C1)=O)=C4)=C4C#CC5=CC=NC6=C5C=NN6
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
541.61
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Zheng Q, Qiu X, Luo D, Ma H, Ming Y, Pu W, Ai M, He J, Peng Y. Optimization
of 1-Methyl-3-(pyridin-3-yl)-1H-indol Derivatives as ROR1 Inhibitors with
Improved Activity and Selectivity. J Med Chem. 2025 Jun 2. doi:
10.1021/acs.jmedchem.5c00189. Epub ahead of print. PMID: 40456695.
2: Zheng Q, Ma H, Luo D, Qiu X, Ming Y, Pu W, Ai M, He J, Peng Y. Structure-
directing optimization of N-(2,3-dihydrobenzo[b] [1,4]dioxin-6-yl)benzamide
derivatives as selective receptor tyrosine kinase-like orphan receptor 1 (ROR1)
inhibitors for cancer therapy. Eur J Med Chem. 2025 Sep 15;294:117755. doi:
10.1016/j.ejmech.2025.117755. Epub 2025 May 13. PMID: 40409056.
