Trigriluzole, a tripeptide derivative of riluzole, exhibits neuroprotective and anticonvulsant activity by modulating glutamate neurotransmission. Preclinical studies show it reduces extracellular glutamate levels by enhancing glutamate uptake via EAAT2 transporters, with an EC50 of ~10 μM in astrocyte cultures. In rodent models of epilepsy, trigriluzole (10–30 mg/kg, oral) significantly decreases seizure frequency and neuronal hyperexcitability. It also demonstrates neuroprotective effects in neurodegenerative models, reducing oxidative stress and apoptosis.
MedKoo Cat#: 333128
Name: Trigriluzole HCl
CAS#: 1926204-76-3 (HCl)
Chemical Formula: C15H17ClF3N5O4S
Exact Mass: 0.0000
Molecular Weight: 455.84
Elemental Analysis: C, 39.52; H, 3.76; Cl, 7.78; F, 12.50; N, 15.36; O, 14.04; S, 7.03
The following data is based on the product molecular weight 455.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
