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MedKoo Cat#: 129006 | Name: SHP1705
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SHP1705 is a small molecule activator and stabilizer of Cryptochrome 2 (CRY2), a core component of the circadian clock. It functions by enhancing CRY2's stability and activity, leading to the repression of circadian genes such as DBP, CRY1, and PER1. This modulation of the circadian rhythm has therapeutic implications in various diseases.

Chemical Structure

SHP1705
SHP1705
CAS#1817737-04-4

Theoretical Analysis

MedKoo Cat#: 129006

Name: SHP1705

CAS#: 1817737-04-4

Chemical Formula: C18H17F2N3O2

Exact Mass: 345.1289

Molecular Weight: 345.35

Elemental Analysis: C, 62.60; H, 4.96; F, 11.00; N, 12.17; O, 9.27

Price and Availability

Size Price Availability Quantity
5mg USD 550.00 2 Weeks
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Related CAS #
No Data
Synonym
SHP1705; SHP-1705; SHP 1705
IUPAC/Chemical Name
1-(3-(3,6-difluoro-9H-carbazol-9-yl)-2-hydroxypropyl)imidazolidin-2-one
InChi Key
MUVYYQQLOKRDQS-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H17F2N3O2/c19-11-1-3-16-14(7-11)15-8-12(20)2-4-17(15)23(16)10-13(24)9-22-6-5-21-18(22)25/h1-4,7-8,13,24H,5-6,9-10H2,(H,21,25)
SMILES Code
C1CN(C(=O)N1)CC(CN2C3=C(C=C(C=C3)F)C4=C2C=CC(=C4)F)O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 345.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chan P, Nagai Y, Wu Q, Hovsepyan A, Mkhitaryan S, Wang J, Karapetyan G, Kamenecka T, Solt LA, Cope J, Moats RA, Hirota T, Rich JN, Kay SA. Advancing Clinical Response Against Glioblastoma: Evaluating SHP1705 CRY2 Activator Efficacy in Preclinical Models and Safety in Phase I Trials. bioRxiv [Preprint]. 2024 Sep 21:2024.09.17.613520. doi: 10.1101/2024.09.17.613520. Update in: Neuro Oncol. 2025 Apr 01:noaf089. doi: 10.1093/neuonc/noaf089. PMID: 39345648; PMCID: PMC11429762. 2: Chan P, Nagai Y, Wu Q, Hovsepyan A, Mkhitaryan S, Wang J, Karapetyan G, Kamenecka T, Solt LA, Cope J, Moats RA, Hirota T, Rich JN, Kay SA. Advancing Clinical Response Against Glioblastoma: Evaluating SHP1705 CRY2 Activator Efficacy in Preclinical Models and Safety in Phase I Trials. Neuro Oncol. 2025 Apr 1:noaf089. doi: 10.1093/neuonc/noaf089. Epub ahead of print. PMID: 40168112.