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MedKoo Cat#: 414978 | Name: Pipofezine Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pipofezine Free Base, sold under the brand name Azafen or Azaphen, is an antidepressant approved in Russia for the treatment of depression. It was introduced in the late 1960s and is still used today. Pipofezine has been shown to act as a potent inhibitor of the reuptake of serotonin.

Chemical Structure

Pipofezine Free Base
Pipofezine Free Base
CAS#24886-52-0 (free base)

Theoretical Analysis

MedKoo Cat#: 414978

Name: Pipofezine Free Base

CAS#: 24886-52-0 (free base)

Chemical Formula: C16H19N5O

Exact Mass: 297.1590

Molecular Weight: 297.36

Elemental Analysis: C, 64.63; H, 6.44; N, 23.55; O, 5.38

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
24886-52-0 (free base); 24853-80-3 (HCl)
Synonym
Pipofezine Free Base; Azafen; Azaphen
IUPAC/Chemical Name
5-Methyl-3-(4-methyl-1-piperazinyl)-5H-pyridazino(3,4-b)(1,4)benzoxazine
InChi Key
SDYYIRPAZHJOLM-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H19N5O/c1-19-7-9-21(10-8-19)15-11-13-16(18-17-15)22-14-6-4-3-5-12(14)20(13)2/h3-6,11H,7-10H2,1-2H3
SMILES Code
CN1CCN(C2=NN=C3OC4=CC=CC=C4N(C)C3=C2)CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 297.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shinaev NN, Akzhigitov RG. [Azaphen: a return to clinical practice]. Zh Nevrol Psikhiatr Im S S Korsakova. 2005;105(10):55-6. Russian. PubMed PMID: 16281382. 2: Ignatowicz L, Ignatowicz R, Wdowiak MW, Jaremko A. [Azaphen in the treatment of enuresis in children]. Psychiatr Pol. 1977 Jan-Feb;11(1):29-33. Polish. PubMed PMID: 557800. 3: Liberman SS, Sharova SA. [A comparison of the effect of the tricyclic antidepressants azaphen and imizin on the gastrointestinal tracts of experimental animals]. Farmakol Toksikol. 1975 Jan-Feb;38(1):29-32. Russian. PubMed PMID: 1112390. 4: Misurec J, Náhunek K, Kamenická V, Chmelar M. Proceedings: Influence of azaphen, a new antidepressive drug, on the human EEG. Act Nerv Super (Praha). 1974;16(4):245-6. PubMed PMID: 4450998. 5: Siniukhin VN. [Absorption and organ distribution of the new antidepressant azaphen]. Farmakol Toksikol. 1973 Jul-Aug;26(4):409-11. Russian. PubMed PMID: 4789881. 6: Andreeva NI. [Effect of the tricyclic antidepressants--imizin, desipramine, amitryptyline and azaphen on gastric secretion in rats]. Farmakol Toksikol. 1972 Jul;35(4):443-5. Russian. PubMed PMID: 5050274. 7: Roshchina LF. [Effect of azaphen on conditioned avoidance reflex in rats]. Farmakol Toksikol. 1971 Nov-Dec;34(6):643-6. Russian. PubMed PMID: 5139777. 8: Kutchak SN, Sharova SA, Egorova EF. [Toxicological study of azaphen]. Farmakol Toksikol. 1971 May-Jun;34(3):291-2. Russian. PubMed PMID: 5568686. 9: Mashkovskiĭ MD, Roshchina LF. [Effect of azaphen on the bioelectric activity of the brain]. Farmakol Toksikol. 1971;34(2):144-8. Russian. PubMed PMID: 5563383. 10: Mashkovskiĭ MD, Polezhaeva AI. [Pharmacological properties of new antidepressive agent azaphen]. Farmakol Toksikol. 1969 Nov-Dec;32(6):656-62. Russian. PubMed PMID: 5381594. 11: Mashkovskii MD, Polezhaeva AI, Avrutskii GIa, Vertozgadova OP, Smulevich AB. [The pharmacologic properties and therapeutic effectiveness of the new antidepressant preparation Azaphen]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1969;69(8):1234-8. Russian. PubMed PMID: 5392529.