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MedKoo Cat#: 146376 | Name: Ensulizole

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ensulizole is a water-soluble, organic compound used as a UVB-filtering agent in sunscreens. It absorbs UVB radiation, helping to protect the skin from sunburn and long-term damage such as photoaging and skin cancer. Unlike some other sunscreen agents, it is photostable and works primarily by absorbing harmful UV rays rather than reflecting them.

Chemical Structure

Ensulizole
Ensulizole
CAS#27503-81-7

Theoretical Analysis

MedKoo Cat#: 146376

Name: Ensulizole

CAS#: 27503-81-7

Chemical Formula: C13H10N2O3S

Exact Mass: 274.0412

Molecular Weight: 274.29

Elemental Analysis: C, 56.93; H, 3.67; N, 10.21; O, 17.50; S, 11.69

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ensulizole;
IUPAC/Chemical Name
2-phenyl-1H-benzo[d]imidazole-6-sulfonic acid
InChi Key
UVCJGUGAGLDPAA-UHFFFAOYSA-N
InChi Code
1S/C13H10N2O3S/c16-19(17,18)10-6-7-11-12(8-10)15-13(14-11)9-4-2-1-3-5-9/h1-8H,(H,14,15)(H,16,17,18)
SMILES Code
OS(=O)(=O)C1=CC2=C(C=C1)N=C(N2)C3=CC=CC=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 274.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Rajamohan R, Kamaraj E, Govindasamy C, Subramanian SA, Kim SJ, Krishnan MM, Murugavel K, Murugan M, Lee YR. Formulation of Ensulizole with Beta- Cyclodextrins for Improved Sunscreen Activity and Biocompatibility. J Pharm Sci. 2024 Jun;113(6):1536-1545. doi: 10.1016/j.xphs.2023.12.019. Epub 2023 Dec 24. PMID: 38147911. 2: Mubeen M, Khalid MA, Mukhtar M, Shahrum S, Zahra S, Shabbir S, Iqbal A. Elucidating the Photoluminescence Quenching in Ensulizole: an Artificial Water Soluble Sunscreen. J Fluoresc. 2021 Jul;31(4):1055-1063. doi: 10.1007/s10895-021-02736-x. Epub 2021 May 6. PMID: 33956267. 3: Pham DN, Sokolov EP, Falfushynska H, Sokolova IM. Gone with sunscreens: Responses of blue mussels (Mytilus edulis) to a wide concentration range of a UV filter ensulizole. Chemosphere. 2022 Dec;309(Pt 1):136736. doi: 10.1016/j.chemosphere.2022.136736. Epub 2022 Oct 6. PMID: 36209850. 4: Nedorost S. Ensulizole (phenylbenzimidazole-5-sulfonic acid) as a cause of facial dermatitis: two cases. Dermatitis. 2005 Sep;16(3):148. doi: 10.1097/01206501-200509000-00014. PMID: 16408354. 5: Melánová K, Kopecká K, Beneš L, Kutálek P, Knotek P, Zmrhalová Z, Svoboda J. Functionalization of ZnAl-Layered Double Hydroxide with Ensulizole and Its Application as a UV-Protective Agent in a Transparent Polymer Coating. Molecules. 2023 Aug 26;28(17):6262. doi: 10.3390/molecules28176262. PMID: 37687092; PMCID: PMC10488424. 6: Falfushynska H, Sokolov EP, Fisch K, Gazie H, Schulz-Bull DE, Sokolova IM. Biomarker-based assessment of sublethal toxicity of organic UV filters (ensulizole and octocrylene) in a sentinel marine bivalve Mytilus edulis. Sci Total Environ. 2021 Dec 1;798:149171. doi: 10.1016/j.scitotenv.2021.149171. Epub 2021 Jul 26. PMID: 34329935. 7: Mubeen M, Ain NU, Khalid MA, Mukhtar M, Naz B, Siddique Z, Ul-Hamid A, Iqbal A. Enhancing the FRET by tuning the bandgap of acceptor ternary ZnCdS quantum dots. RSC Adv. 2023 Jun 23;13(28):19096-19105. doi: 10.1039/d3ra03233g. PMID: 37362335; PMCID: PMC10288831. 8: Hamadeh A, Nash JF, Bialk H, Styczynski P, Troutman J, Edginton A. Mechanistic Skin Modeling of Plasma Concentrations of Sunscreen Active Ingredients Following Facial Application. J Pharm Sci. 2024 Mar;113(3):806-825. doi: 10.1016/j.xphs.2023.09.017. Epub 2023 Sep 26. PMID: 37769994. 9: Cohen SM, Boobis AR, Jacobson-Kram D, Schoeny R, Rosol TJ, Williams GM, Kaminski NE, Eichenbaum GM, Guengerich FP, Nash JF. Mode of action approach supports a lack of carcinogenic potential of six organic UV filters. Crit Rev Toxicol. 2025 Feb;55(2):248-284. doi: 10.1080/10408444.2025.2462642. Epub 2025 Apr 10. PMID: 40208192. 10: Lintner M, Schagerl M, Lintner B, Nagy M, Heinz P. Photosynthetic performance of symbiont-bearing foraminifera Heterostegina depressa affected by sunscreens. Sci Rep. 2022 Feb 17;12(1):2750. doi: 10.1038/s41598-022-06735-1. PMID: 35177723; PMCID: PMC8854690. 11: Kim D, Kim S, Kim SA, Choi M, Kwon KJ, Kim M, Kim DS, Kim SH, Choi BK. Simultaneous analysis and monitoring of 16 UV filters in cosmetics by high- performance liquid chromatography. J Cosmet Sci. 2012 Mar-Apr;63(2):103-17. PMID: 22591562. 12: Shokri J, Hasanzadeh D, Ghanbarzadeh S, Dizadji-Ilkhchi M, Adibkia K. The effect of Beta-cyclodextrin on percutaneous absorption of commonly used Eusolex® sunscreens. Drug Res (Stuttg). 2013 Nov;63(11):591-6. doi: 10.1055/s-0033-1349089. Epub 2013 Jul 10. PMID: 23842944. 13: Godejohann M, Berset JD, Muff D. Non-targeted analysis of wastewater treatment plant effluents by high performance liquid chromatography-time slice- solid phase extraction-nuclear magnetic resonance/time-of-flight-mass spectrometry. J Chromatogr A. 2011 Dec 23;1218(51):9202-9. doi: 10.1016/j.chroma.2011.10.051. Epub 2011 Oct 28. PMID: 22098937. 14: Ding C, Wu J, Liu Y, Sheng X, Cheng X, Xiong X, Zhao W. A Waterborne Epoxy Composite Coating with Smart Corrosion Resistance Based on 2-Phenylbenzimidazole-5-sulfonic Acid/Layered Double Hydroxide Composite. Molecules. 2023 Jul 4;28(13):5199. doi: 10.3390/molecules28135199. PMID: 37446859; PMCID: PMC10343620. 15: Malinovska V, Kuklina I, Grabicová K, Buřič M, Kozák P. Short-term effects of an environmentally relevant concentration of organic UV filters on signal crayfish Pacifastacus leniusculus. Ecotoxicol Environ Saf. 2023 Jul 1;259:115012. doi: 10.1016/j.ecoenv.2023.115012. Epub 2023 May 18. PMID: 37209570. 16: Azevedo JS, Viana Junior NS, Vianna Soares CD. UVA/UVB sunscreen determination by second-order derivative ultraviolet spectrophotometry. Farmaco. 1999 Sep 30;54(9):573-8. doi: 10.1016/s0014-827x(99)00063-4. PMID: 10555257. 17: Abdelraheem WH, He X, Duan X, Dionysiou DD. Degradation and mineralization of organic UV absorber compound 2-phenylbenzimidazole-5-sulfonic acid (PBSA) using UV-254nm/H2O2. J Hazard Mater. 2015 Jan 23;282:233-40. doi: 10.1016/j.jhazmat.2014.07.041. Epub 2014 Jul 29. PMID: 25123523. 18: Hu C, Xiong C, Lin YL, Zhu Y, Wang Q, Xu L, Huang D. Degradation of 2-phenylbenzimidazole 5-sulfonic acid by UV/chlorine advanced oxidation technology: Kinetic model, degradation byproducts and reaction pathways. J Hazard Mater. 2022 Jun 5;431:128574. doi: 10.1016/j.jhazmat.2022.128574. Epub 2022 Mar 1. PMID: 35278948. 19: Orlikowska A, Fisch K, Schulz-Bull DE. Organic polar pollutants in surface waters of inland seas. Mar Pollut Bull. 2015 Dec 30;101(2):860-6. doi: 10.1016/j.marpolbul.2015.11.018. Epub 2015 Nov 12. PMID: 26581813. 20: Barrientos N, Abajo P, de Celada RA, de Vega MM, Domínguez J. Allergic contact dermatitis caused by phenylbenzimidazole sulfonic acid included in a sunscreen. Contact Dermatitis. 2019 Aug;81(2):151-152. doi: 10.1111/cod.13271. Epub 2019 May 7. PMID: 30891767.

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