6K465 | An AURKA inhibitor | CAS#2702965-27-1

MedKoo Cat#: 128957 | Name: 6K465

Description:

WARNING: This product is for research use only, not for human or veterinary use.

6K465 is a pyrimidine-based Aurora A (AURKA) inhibitor.

Chemical Structure

6K465

CAS#2702965-27-1

Theoretical Analysis

MedKoo Cat#: 128957

Name: 6K465

CAS#: 2702965-27-1

Chemical Formula: C26H33ClFN9O

Exact Mass: 541.2481

Molecular Weight: 542.06

Elemental Analysis: C, 57.61; H, 6.14; Cl, 6.54; F, 3.50; N, 23.26; O, 2.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

6K465; 6K-465; 6-K-465

IUPAC/Chemical Name

(3-chloro-2-fluorophenyl)(4-((4-(4-ethylpiperazin-1-yl)-6-((5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)amino)piperidin-1-yl)methanone

InChi Key

NKCRCYYIMDOKFP-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H33ClFN9O/c1-3-35-11-13-36(14-12-35)23-16-21(30-22-15-17(2)33-34-22)31-26(32-23)29-18-7-9-37(10-8-18)25(38)19-5-4-6-20(27)24(19)28/h4-6,15-16,18H,3,7-14H2,1-2H3,(H3,29,30,31,32,33,34)

SMILES Code

O=C(N1CCC(NC2=NC(N3CCN(CC)CC3)=CC(NC4=NNC(C)=C4)=N2)CC1)C5=CC=CC(Cl)=C5F

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 542.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Chang CP, Yeh TK, Chen CT, Wang WP, Chen YT, Tsai CH, Chen YF, Ke YY, Wang JY, Chen CP, Hsieh TC, Wu MH, Huang CL, Chen YP, Zhuang H, Chi YH. Discovery of a Long Half-Life AURKA Inhibitor to Treat MYC-Amplified Solid Tumors as a Monotherapy and in Combination with Everolimus. Mol Cancer Ther. 2024 Jun 4;23(6):766-779. doi: 10.1158/1535-7163.MCT-23-0602. PMID: 38592383.