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MedKoo Cat#: 128951 | Name: INCB126503

Description:

WARNING: This product is for research use only, not for human or veterinary use.

INCB126503 is a highly potent, orally bioavailable FGFR2/3 inhibitor with excellent isoform selectivity and equipotent activity against gatekeeper mutants. INCB126503effectively suppresses FGFR signaling in vivo without inducing hyperphosphatemia and demonstrates significant antitumor efficacy in xenograft models harboring FGFR3 genetic alterations.

Chemical Structure

INCB126503
INCB126503
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128951

Name: INCB126503

CAS#: N/A

Chemical Formula: C27H30N6O2

Exact Mass: 470.2430

Molecular Weight: 470.58

Elemental Analysis: C, 68.91; H, 6.43; N, 17.86; O, 6.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
INCB126503; INCB 126503; INCB-126503
IUPAC/Chemical Name
(7R,8aS)-2-(5-(5-(2,3-dimethylphenyl)-6-methoxy-1H-pyrazolo[4,3-b]pyridin-3-yl)pyridin-2-yl)octahydropyrrolo[1,2-a]pyrazin-7-ol
InChi Key
ZBHJWDKPRTVNKG-VQTJNVASSA-N
InChi Code
InChI=1S/C27H30N6O2/c1-16-5-4-6-21(17(16)2)26-23(35-3)12-22-27(29-26)25(31-30-22)18-7-8-24(28-13-18)33-10-9-32-15-20(34)11-19(32)14-33/h4-8,12-13,19-20,34H,9-11,14-15H2,1-3H3,(H,30,31)/t19-,20+/m0/s1
SMILES Code
CC1=CC=CC(C2=NC3=C(NN=C3C4=CN=C(N5C[C@@](C[C@@H](O)C6)([H])N6CC5)C=C4)C=C2OC)=C1C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 470.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Discovery of INCB126503 as a Potent and Selective FGFR2/3 Inhibitor Minh H. Nguyen, Anlai Wang, Lisa Truong, Ke Zhang, Hai-Fen Ye, Peng Zhao, April Horsey, Michelle Frascella, Lynn Leffet, Kelly Federowicz, Elham Behshad, Michael R. Witten, Chao Qi, Yao Xu, Ravi Jalluri, Jennifer J. Harris, Rodrigo Hess, Brian Sayers, Luping Lin, Swamy Yeleswaram, Guofeng Zhang, Sunkyu Kim, Maryanne Covington, Sharon Diamond, Wenqing Yao, and Oleg Vechorkin ACS Medicinal Chemistry Letters Article ASAP DOI: 10.1021/acsmedchemlett.5c00232

View History

L 2010

L 2010